Wnt signaling pathway and pluripotency (WP1288)

Rattus norvegicus

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.


Kristina Hanspers , Daniela Digles , Eric Weitz , and Lars Willighagen


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Rattus norvegicus



Pathway Ontology

Wnt signaling, canonical pathway


Label Type Compact URI Comment
Fzd8 GeneProduct ncbigene:364754
Apc GeneProduct ncbigene:24205
Ctbp1 GeneProduct ncbigene:29382
Mmp7 GeneProduct ncbigene:25335
DVL2 GeneProduct ncbigene:303251
Ctnnb1 GeneProduct ncbigene:84353
Wnt3a GeneProduct ncbigene:303181
Jun GeneProduct ncbigene:24516
Nfya GeneProduct ensembl:ENSRNOG00000012702
Prkci GeneProduct ncbigene:84006
Wnt10b GeneProduct ncbigene:315294
Plau GeneProduct ncbigene:25619
Wnt2b GeneProduct ncbigene:116466
Crebbp GeneProduct ncbigene:54244
Ppp2ca GeneProduct ncbigene:24672
Ppp2cb GeneProduct ncbigene:24673
Tcf7_predicted GeneProduct ensembl:ENSRNOG00000005872
LOC679869 GeneProduct ensembl:ENSRNOG00000013993
Prkca GeneProduct ncbigene:24680
Lef1 GeneProduct ncbigene:161452
Sox2 GeneProduct ncbigene:499593
Zbtb33 GeneProduct ncbigene:501506
Racgap1 GeneProduct ncbigene:315298
Mapk10 GeneProduct ncbigene:25272
Fzd2 GeneProduct ncbigene:64512
Wnt16 GeneProduct ncbigene:500047
Wnt2 GeneProduct ncbigene:114487
Wnt9b GeneProduct ncbigene:303586
Wnt5a GeneProduct ncbigene:64566
Ppp2r1a GeneProduct ncbigene:117281
Tcf3 GeneProduct ncbigene:312451
Ppard GeneProduct ncbigene:25682
Ep300 GeneProduct ncbigene:170915
Prkcq GeneProduct ncbigene:85420
Fbxw2 GeneProduct ncbigene:311881
Nlk GeneProduct ncbigene:497961
Ppm1j GeneProduct ensembl:ENSRNOG00000012481
Wnt1 GeneProduct ncbigene:24881
Prkcb GeneProduct ncbigene:25023
Prkd1 GeneProduct ncbigene:85421
Foxd3 GeneProduct ensembl:ENSRNOG00000009021
Myc GeneProduct ncbigene:24577
Wnt6 GeneProduct ncbigene:316526
Dvl1 GeneProduct ncbigene:83721
Pafah1b1 GeneProduct ncbigene:83572
Wnt11 GeneProduct ncbigene:140584
Tp53 GeneProduct ncbigene:24842
Ccnd1 GeneProduct ncbigene:58919
Wnt3 GeneProduct ncbigene:24882
Ppp2r2b GeneProduct ncbigene:60660
Mapk9 GeneProduct ncbigene:50658
Pou5f1 GeneProduct ncbigene:294562
Wnt7a GeneProduct ncbigene:114850
Ctbp2 GeneProduct ncbigene:81717
Ppp2r1b GeneProduct ncbigene:315648
Ppp2r5e GeneProduct ncbigene:299147
Prkcz GeneProduct ncbigene:25522
Lrp6 GeneProduct ncbigene:312781
Fzd4 GeneProduct ncbigene:64558
Dvl3 GeneProduct ncbigene:303811
Fosl1 GeneProduct ncbigene:25445
Axin2 GeneProduct ncbigene:29134
Fzd9 GeneProduct ncbigene:266608
Rhoa GeneProduct ncbigene:117273
Fzd6 GeneProduct ncbigene:282581
Nkd1 GeneProduct ncbigene:364952
FZD7 GeneProduct ncbigene:301440
Nkd2 GeneProduct ncbigene:308068
Axin1 GeneProduct ncbigene:79257
Nanog GeneProduct ncbigene:414065
Ppp2r5c GeneProduct ncbigene:691318
Gsk3b GeneProduct ncbigene:84027
Wnt4 GeneProduct ncbigene:84426
Ppp2r2a GeneProduct ncbigene:117104
Csnk1e GeneProduct ncbigene:58822
Ppp2r2c GeneProduct ncbigene:117256
FZD3 GeneProduct ncbigene:266715
Ctnnd1 GeneProduct ncbigene:311163
Wnt10a GeneProduct ncbigene:316527
Ldlr GeneProduct ncbigene:300438
Map3k7 GeneProduct ncbigene:313121
Wnt11 GeneProduct ncbigene:140584 Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
Prkce GeneProduct ncbigene:29340
Fzd5 GeneProduct ncbigene:317674
Ccnd3 GeneProduct ncbigene:25193
Ppp2r3a GeneProduct ncbigene:363122
Prkch GeneProduct ncbigene:81749
Cd44 GeneProduct ncbigene:25406
Wnt7b GeneProduct ncbigene:315196
Wnt5b GeneProduct ncbigene:282582
Fzd1 GeneProduct ncbigene:58868
Prkcd GeneProduct ncbigene:170538
Ppp2r4 GeneProduct ncbigene:362102
Lrp5 GeneProduct ncbigene:293649
Ccnd2 GeneProduct ncbigene:64033


  1. KEGG Pathway: hsa04310
  2. Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Sato N, Brivanlou AH. Methods Mol Biol. 2006;331:115–28. PubMed Europe PMC Scholia
  3. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia