Mesodermal commitment pathway (WP3183)

Bos taurus

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Model depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109

Authors

Martina Summer-Kutmon , Elisa Cirillo , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
HES7 GeneProduct ensembl:ENSBTAG00000012436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179111
DLL1 GeneProduct ensembl:ENSBTAG00000031476 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198719
bta-mir-302c GeneProduct ensembl:ENSBTAG00000036429 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199102
TBX6 GeneProduct ensembl:ENSBTAG00000009046 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149922
SMAD6 GeneProduct ensembl:ENSBTAG00000000625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137834
LATS1 GeneProduct ensembl:ENSBTAG00000015076 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131023
POU5F1 GeneProduct ensembl:ENSBTAG00000001873 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204531
MIXL1 GeneProduct ensembl:ENSBTAG00000002139 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185155
SOX2 GeneProduct ensembl:ENSBTAG00000011598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449
LEFTY1 GeneProduct ensembl:ENSBTAG00000002855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243709
SOX17 GeneProduct ensembl:ENSBTAG00000005748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164736
LEFTY2 GeneProduct ensembl:ENSBTAG00000002855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143768
NANOG GeneProduct ensembl:ENSBTAG00000020916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111704
FZD4 GeneProduct ensembl:ENSBTAG00000040128 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174804
FZD5 GeneProduct ensembl:ENSBTAG00000020957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163251
FZD8 GeneProduct ensembl:ENSBTAG00000015072 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177283
FGF8 GeneProduct ensembl:ENSBTAG00000001530 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831
AXIN2 GeneProduct ensembl:ENSBTAG00000030162 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168646
NFE2L2 GeneProduct ensembl:ENSBTAG00000019255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116044
SOX2 GeneProduct ensembl:ENSBTAG00000011598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449

References

  1. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP. Genes Dev. 1999 Dec 15;13(24):3185–90. PubMed Europe PMC Scholia
  2. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Bessho Y, Miyoshi G, Sakata R, Kageyama R. Genes Cells. 2001 Feb;6(2):175–85. PubMed Europe PMC Scholia
  3. Dll1 is a downstream target of Tbx6 in the paraxial mesoderm. White PH, Chapman DL. Genesis. 2005 Jul;42(3):193–202. PubMed Europe PMC Scholia
  4. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. Barroso-delJesus A, Lucena-Aguilar G, Sanchez L, Ligero G, Gutierrez-Aranda I, Menendez P. FASEB J. 2011 May;25(5):1497–508. PubMed Europe PMC Scholia
  5. Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, et al. Nature. 2011 Feb 17;470(7334):394–8. PubMed Europe PMC Scholia
  6. miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in human embryonic stem cells. Wong SSY, Ritner C, Ramachandran S, Aurigui J, Pitt C, Chandra P, et al. PLoS One. 2012;7(4):e36121. PubMed Europe PMC Scholia