Chicken limb development (WP2587)

Gallus gallus

"The mechanisms regulating the vertebrate limb mesenchyme of chickens, have been extensively discussed in literature. There are currently two models. The first regards that progressive distalization of limb pattern is based on an autonomous clocklike mechanism, inherent to the undifferentiated mesenchymal cells. The second belives that instructive cues from surrounding tissues are responsible for specifying the PD segments (adapted from Cooper et al. 2011 [])." This pathway visualises the different steps in limb development, with corresponding literature.


Josh Loebs , Anders Riutta , Denise Slenter , Egon Willighagen , and Eric Weitz


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Gallus gallus



Pathway Ontology

regulatory pathway signaling pathway pertinent to development


Label Type Compact URI Comment
RETINOIC ACID Metabolite chebi:15367 Lateral Plate Mesoderm
Retinoic Acid Metabolite chebi:15367
Fgf8 GeneProduct ensembl:ENSGALG00000007706
Shh GeneProduct ensembl:ENSGALG00000006379
HOXA13 GeneProduct ensembl:ENSGALG00000027234
Myf5 GeneProduct ensembl:ENSGALG00000028091
FGF10 GeneProduct ensembl:ENSGALG00000014872 Lateral Plate Mesoderm
Hoxc10 GeneProduct ensembl:ENSGALG00000029393
Pax3 GeneProduct ensembl:ENSGALG00000005246
Wnt8c GeneProduct ensembl:ENSGALG00000037494 Ectoderm
GREM1 GeneProduct ensembl:ENSGALG00000009724
Wnt2b GeneProduct ensembl:ENSGALG00000029570 Ectoderm
FGF8 GeneProduct ensembl:ENSGALG00000007706 Ectoderm
Shh GeneProduct ensembl:ENSGALG00000006379
TBX5 GeneProduct ensembl:ENSGALG00000008253 Tbx5 in forelimb. Lateral Plate Mesoderm
TBX4 GeneProduct ensembl:ENSGALG00000005285 Tbx4 in hindlimb. Lateral Plate Mesoderm
SHH GeneProduct ensembl:ENSGALG00000006379
MEIS1 GeneProduct ensembl:ENSGALG00000041626
PITX1 GeneProduct ensembl:ENSGALG00000030237 Hindlimb-specific
TBX1 GeneProduct ensembl:ENSGALG00000041182
Myod GeneProduct ensembl:ENSGALG00000006216
FGF9 GeneProduct ensembl:ENSGALG00000025748
WNT3A GeneProduct ensembl:ENSGALG00000042657
HOXA11 GeneProduct ensembl:ENSGALG00000040021
FGF4 GeneProduct ensembl:ENSGALG00000007562
PITX2 GeneProduct ensembl:ENSGALG00000042492
Noggin Protein uniprot:F1NAM3


  1. An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Verheyden JM, Sun X. Nature. 2008 Jul 31;454(7204):638–41. PubMed Europe PMC Scholia
  2. Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5489–94. PubMed Europe PMC Scholia
  3. Regulation of limb bud initiation and limb-type morphology. Duboc V, Logan MPO. Dev Dyn. 2011 May;240(5):1017–27. PubMed Europe PMC Scholia
  4. Initiation of proximal-distal patterning in the vertebrate limb by signals and growth. Cooper KL, Hu JKH, ten Berge D, Fernandez-Teran M, Ros MA, Tabin CJ. Science. 2011 May 27;332(6033):1083–6. PubMed Europe PMC Scholia
  5. Evolution and development of the vertebrate neck. Ericsson R, Knight R, Johanson Z. J Anat. 2013 Jan;222(1):67–78. PubMed Europe PMC Scholia