Chicken limb development (WP2587)
Gallus gallus
"The mechanisms regulating the vertebrate limb mesenchyme of chickens, have been extensively discussed in literature. There are currently two models. The first regards that progressive distalization of limb pattern is based on an autonomous clocklike mechanism, inherent to the undifferentiated mesenchymal cells. The second belives that instructive cues from surrounding tissues are responsible for specifying the PD segments (adapted from Cooper et al. 2011 [https://www.ncbi.nlm.nih.gov/pubmed/21617075])." This pathway visualises the different steps in limb development, with corresponding literature.
Authors
Josh Loebs , Anders Riutta , Denise Slenter , Egon Willighagen , and Eric WeitzActivity
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Cited In
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Organisms
Gallus gallusCommunities
Annotations
Pathway Ontology
regulatory pathway signaling pathway pertinent to development| Label | Type | Compact URI | Comment |
|---|---|---|---|
| RETINOIC ACID | Metabolite | chebi:15367 | Lateral Plate Mesoderm |
| Retinoic Acid | Metabolite | chebi:15367 | |
| Fgf8 | GeneProduct | ensembl:ENSGALG00000007706 | |
| Shh | GeneProduct | ensembl:ENSGALG00000006379 | |
| HOXA13 | GeneProduct | ensembl:ENSGALG00000027234 | |
| Myf5 | GeneProduct | ensembl:ENSGALG00000028091 | |
| FGF10 | GeneProduct | ensembl:ENSGALG00000014872 | Lateral Plate Mesoderm |
| Hoxc10 | GeneProduct | ensembl:ENSGALG00000029393 | |
| Pax3 | GeneProduct | ensembl:ENSGALG00000005246 | |
| Wnt8c | GeneProduct | ensembl:ENSGALG00000037494 | EctodermHindlimb |
| GREM1 | GeneProduct | ensembl:ENSGALG00000009724 | |
| Wnt2b | GeneProduct | ensembl:ENSGALG00000029570 | EctodermForelimb |
| FGF8 | GeneProduct | ensembl:ENSGALG00000007706 | Ectoderm |
| Shh | GeneProduct | ensembl:ENSGALG00000006379 | |
| TBX5 | GeneProduct | ensembl:ENSGALG00000008253 | Tbx5 in forelimb. Lateral Plate Mesoderm |
| TBX4 | GeneProduct | ensembl:ENSGALG00000005285 | Tbx4 in hindlimb. Lateral Plate Mesoderm |
| SHH | GeneProduct | ensembl:ENSGALG00000006379 | |
| MEIS1 | GeneProduct | ensembl:ENSGALG00000041626 | |
| PITX1 | GeneProduct | ensembl:ENSGALG00000030237 | Hindlimb-specific |
| TBX1 | GeneProduct | ensembl:ENSGALG00000041182 | |
| Myod | GeneProduct | ensembl:ENSGALG00000006216 | |
| FGF9 | GeneProduct | ensembl:ENSGALG00000025748 | |
| WNT3A | GeneProduct | ensembl:ENSGALG00000042657 | |
| HOXA11 | GeneProduct | ensembl:ENSGALG00000040021 | |
| FGF4 | GeneProduct | ensembl:ENSGALG00000007562 | |
| PITX2 | GeneProduct | ensembl:ENSGALG00000042492 | |
| Noggin | Protein | uniprot:F1NAM3 |
References
- An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Verheyden JM, Sun X. Nature. 2008 Jul 31;454(7204):638–41. PubMed Europe PMC Scholia
- Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5489–94. PubMed Europe PMC Scholia
- Regulation of limb bud initiation and limb-type morphology. Duboc V, Logan MPO. Dev Dyn. 2011 May;240(5):1017–27. PubMed Europe PMC Scholia
- Initiation of proximal-distal patterning in the vertebrate limb by signals and growth. Cooper KL, Hu JKH, ten Berge D, Fernandez-Teran M, Ros MA, Tabin CJ. Science. 2011 May 27;332(6033):1083–6. PubMed Europe PMC Scholia
- Evolution and development of the vertebrate neck. Ericsson R, Knight R, Johanson Z. J Anat. 2013 Jan;222(1):67–78. PubMed Europe PMC Scholia