Estrogen receptor pathway (WP2881)
Homo sapiens
The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2881 CPTAC Assay Portal]
Authors
Rianne Fijten , Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Susan Coort , Alex Pico , and Eric WeitzActivity
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Cited In
- Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease (2021).
- Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
estrogen signaling pathwayReferences
- Estrogen receptors: therapies targeted to receptor subtypes. Nilsson S, Gustafsson JÅ. Clin Pharmacol Ther. 2011 Jan;89(1):44–55. PubMed Europe PMC Scholia
- Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia