GDNF/RET signaling axis (WP4820)

Mus musculus

GDNF-RET signalling is at the core of the signalling network in kidney development. These signalling interactions between the metanephric mesenchyme and the nephric duct are crucial to ensure the induction of the ureter from the nephric duct.


S. Arnouts , Friederike Ehrhart , Eric Weitz , and Lars Willighagen


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Mus musculus



Pathway Ontology

regulatory pathway

Disease Ontology



Label Type Compact Identifier Comment
Spry1 GeneProduct ensembl:ENSMUSG00000037211
Foxc1 GeneProduct ensembl:ENSMUSG00000050295
Sox17 GeneProduct ensembl:ENSMUSG00000025902
Eya1 GeneProduct ensembl:ENSMUSG00000025932
Sox11 GeneProduct ensembl:ENSMUSG00000063632
Pax2 GeneProduct ensembl:ENSMUSG00000004231
Sall1 GeneProduct ensembl:ENSMUSG00000031665
Agtr2 GeneProduct ensembl:ENSMUSG00000068122
Foxc2 GeneProduct ensembl:ENSMUSG00000046714
Gdnf GeneProduct ensembl:ENSMUSG00000022144
Gata3 GeneProduct ensembl:ENSMUSG00000015619
Fat4 GeneProduct ensembl:ENSMUSG00000046743
Robo2 GeneProduct ensembl:ENSMUSG00000052516
Bmp4 GeneProduct ensembl:ENSMUSG00000021835
Lim1 GeneProduct ensembl:ENSMUSG00000018698
Slit2 GeneProduct ensembl:ENSMUSG00000031558
Grem1 GeneProduct ensembl:ENSMUSG00000074934
Gdnf GeneProduct ensembl:ENSMUSG00000022144
Ret Protein uniprot:P35546
Gfra1 Protein uniprot:P97785
Gli3r Protein uniprot:Q61602
Ift27 Protein uniprot:Q9D0P8
Ift25 Protein uniprot:Q9D6H2
β-cat Protein uniprot:Q02248


  1. Duplex kidney formation: developmental mechanisms and genetic predisposition. Kozlov VM, Schedl A. F1000Res. 2020 Jan 6;9:F1000 Faculty Rev-2. PubMed Europe PMC Scholia