MAP3K1 role in promoting and blocking gonadal determination (WP4872)

Homo sapiens

This pathway summarizes the differential signaling in sex development in the human fetus. Disorders of sex development can derive from dysfunction of one or more genes in this pathway.

Authors

Yves Tilmans and Friederike Ehrhart

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

46,XY sex reversal 46 XX gonadal dysgenesis gonadal dysgenesis

Pathway Ontology

signaling pathway

Participants

Label Type Compact URI Comment
MAPK1 GeneProduct ensembl:ENSG00000100030
WNT4 GeneProduct ensembl:ENSG00000162552
MAP3K4 GeneProduct ensembl:ENSG00000085511
ROCK1 GeneProduct ensembl:ENSG00000067900
MAP3K1 GeneProduct ensembl:ENSG00000095015
FGFR2 GeneProduct ensembl:ENSG00000066468
AXIN1 GeneProduct ensembl:ENSG00000103126
MAP3K1 GeneProduct ensembl:ENSG00000095015
MAP3K4 GeneProduct ensembl:ENSG00000085511
FRAT1 GeneProduct ensembl:ENSG00000165879
RHOA GeneProduct ensembl:ENSG00000067560
SOX9 GeneProduct ensembl:ENSG00000125398
AXIN1 GeneProduct ensembl:ENSG00000103126
AXIN1 GeneProduct ensembl:ENSG00000103126
FOXL2 GeneProduct ensembl:ENSG00000183770
RHOA GeneProduct ensembl:ENSG00000067560
MAPK11 GeneProduct ensembl:ENSG00000185386
GSK3B GeneProduct ensembl:ENSG00000082701
GADD45G GeneProduct ensembl:ENSG00000130222
SRY GeneProduct ensembl:ENSG00000184895
ROCK1 GeneProduct ensembl:ENSG00000067900
MAPK11 GeneProduct ensembl:ENSG00000185386
GSK3B GeneProduct ensembl:ENSG00000082701
FGF9 GeneProduct ensembl:ENSG00000102678
SOX9 GeneProduct ensembl:ENSG00000125398
MAPK1 GeneProduct ensembl:ENSG00000100030
Catenin beta-1 Protein uniprot:B4DGU4
Catenin beta-1 Protein uniprot:B4DGU4

References

  1. Disorders of sex development (DSDs): an update. Ostrer H. J Clin Endocrinol Metab. 2014 May;99(5):1503–9. PubMed Europe PMC Scholia