Blood clotting cascade (WP272)

Homo sapiens

Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: [[wikipedia:Coagulation|Wikipedia]] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Andrew Kwa , Kristina Hanspers , Thomas Kelder , Andra Waagmeester , Luis , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

coagulation cascade pathway


Label Type Compact URI Comment
Fibrin Metabolite chebi:5054
Zinc Metabolite hmdb:HMDB0015532
Factor XIIa GeneProduct ensembl:ENSG00000131187
Factor XIIIa GeneProduct ensembl:ENSG00000143278
Factor IXa GeneProduct ensembl:ENSG00000101981
Factor VIIIa GeneProduct ensembl:ENSG00000185010
Factor XIa GeneProduct ensembl:ENSG00000088926
Factor VIIa GeneProduct ensembl:ENSG00000057593
Factor X GeneProduct ensembl:ENSG00000126218
Factor II GeneProduct ensembl:ENSG00000180210
Factor XII GeneProduct ensembl:ENSG00000131187
KLKB1 GeneProduct ensembl:ENSG00000164344
FGG GeneProduct ensembl:ENSG00000171557
Factor X GeneProduct ensembl:ENSG00000126218
Plasminogen GeneProduct ensembl:ENSG00000122194
Tissue Factor GeneProduct ensembl:ENSG00000117525
Factor Va GeneProduct ensembl:ENSG00000198734
Factor IX GeneProduct ensembl:ENSG00000101981
Factor VIII A1 GeneProduct ensembl:ENSG00000277203
Thrombin (II) GeneProduct ensembl:ENSG00000180210
PLAU GeneProduct ensembl:ENSG00000122861
FGB GeneProduct ensembl:ENSG00000171564
KLK1 GeneProduct ensembl:ENSG00000167748
VWF GeneProduct ensembl:ENSG00000110799
Factor V GeneProduct ensembl:ENSG00000198734
Factor XIIIb GeneProduct ensembl:ENSG00000143278
Factor Xa GeneProduct ensembl:ENSG00000126218
Factor XI GeneProduct ensembl:ENSG00000088926
SERPINF2 GeneProduct ensembl:ENSG00000167711
tPA GeneProduct ensembl:ENSG00000104368
SERPINB2 GeneProduct ensembl:ENSG00000197632
SERPINE1 GeneProduct ensembl:ENSG00000106366
Factor VIII GeneProduct ensembl:ENSG00000185010
Factor VII GeneProduct ensembl:ENSG00000057593
FGA GeneProduct ensembl:ENSG00000171560
Plasmin GeneProduct ensembl:ENSG00000122194
Factor Va GeneProduct ensembl:ENSG00000198734
Factor Xa GeneProduct ensembl:ENSG00000126218


  1. The current status of coagulation. Luchtman-Jones L, Broze GJ Jr. Ann Med. 1995 Feb;27(1):47–52. PubMed Europe PMC Scholia