Frustrated phagocytosis leading to malignant pleural mesothelioma (WP5091)

Homo sapiens

Adverse Outcome Pathway for malignant pleural mesothelioma, known to be initiated by asbestos and carbon nanotubes. This molecular AOP is based on


Marvin Martens , Eric Weitz , Alexandra Bosch , Martina Summer-Kutmon , and PhilipErnst


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Homo sapiens


Adverse Outcome Pathways


Disease Ontology

malignant pleural mesothelioma

Cell Type Ontology

mesothelial cell

Pathway Ontology

disease pathway


Label Type Compact URI Comment


  1. Recent progress and perspectives on the mechanisms underlying Asbestos toxicity. Kuroda A. Genes Environ. 2021 Oct 12;43(1):46. PubMed Europe PMC Scholia
  2. Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms? Gupta SS, Singh KP, Gupta S, Dusinska M, Rahman Q. Nanomaterials (Basel). 2022 May 17;12(10):1708. PubMed Europe PMC Scholia