Dysregulated miRNA targeting in insulin/PI3K-AKT signaling (WP3855)

Mus musculus

This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.


AAR&Co , Martina Summer-Kutmon , Kristina Hanspers , Eric Weitz , and Egon Willighagen


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Mus musculus



Disease Ontology

type 2 diabetes mellitus glucose intolerance

Pathway Ontology

regulatory pathway


Label Type Compact Identifier Comment
Rheb GeneProduct ensembl:ENSMUSG00000028945
Socs1 GeneProduct ensembl:ENSMUSG00000038037
Eif4e2 GeneProduct ensembl:ENSMUSG00000026254
Prkx GeneProduct ensembl:ENSMUSG00000035725
Crkl GeneProduct ensembl:ENSMUSG00000006134
Bad GeneProduct ensembl:ENSMUSG00000024959
Acaca GeneProduct ensembl:ENSMUSG00000020532
Pik3r1 GeneProduct ensembl:ENSMUSG00000041417
Prkar2a GeneProduct ensembl:ENSMUSG00000032601
Sos1 GeneProduct ensembl:ENSMUSG00000024241
Pik3r3 GeneProduct ensembl:ENSMUSG00000028698
Fasn GeneProduct ensembl:ENSMUSG00000025153
Exoc7 GeneProduct ensembl:ENSMUSG00000020792
Mapk3 GeneProduct ensembl:ENSMUSG00000063065
Flot2 GeneProduct ensembl:ENSMUSG00000061981
Raf1 GeneProduct ensembl:ENSMUSG00000000441
Mtor GeneProduct ensembl:ENSMUSG00000028991
Ccnd2 GeneProduct ensembl:ENSMUSG00000000184
Cdkn1b GeneProduct ensembl:ENSMUSG00000003031
Bcl2 GeneProduct ensembl:ENSMUSG00000057329
Col3a1 GeneProduct ensembl:ENSMUSG00000026043
Col1a1 GeneProduct ensembl:ENSMUSG00000001506
Col1a2 GeneProduct ensembl:ENSMUSG00000029661
Col5a3 GeneProduct ensembl:ENSMUSG00000004098
Bcl2l11 GeneProduct ensembl:ENSMUSG00000027381
Col4a2 GeneProduct ensembl:ENSMUSG00000031503


  1. MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling. Kwon DN, Chang BS, Kim JH. Biomed Res Int. 2014;2014:236385. PubMed Europe PMC Scholia