Dysregulated miRNA targeting in insulin/PI3K-AKT signaling (WP3855)

Mus musculus

This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.


AAR&Co , Martina Summer-Kutmon , Kristina Hanspers , Eric Weitz , and Egon Willighagen


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus



Disease Ontology

type 2 diabetes mellitus glucose intolerance

Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
Col3a1 GeneProduct ensembl:ENSMUSG00000026043
Flot2 GeneProduct ensembl:ENSMUSG00000061981
Col1a2 GeneProduct ensembl:ENSMUSG00000029661
Ccnd2 GeneProduct ensembl:ENSMUSG00000000184
Mtor GeneProduct ensembl:ENSMUSG00000028991
Col5a3 GeneProduct ensembl:ENSMUSG00000004098
Sos1 GeneProduct ensembl:ENSMUSG00000024241
Socs1 GeneProduct ensembl:ENSMUSG00000038037
Fasn GeneProduct ensembl:ENSMUSG00000025153
Acaca GeneProduct ensembl:ENSMUSG00000020532
Bcl2l11 GeneProduct ensembl:ENSMUSG00000027381
Eif4e2 GeneProduct ensembl:ENSMUSG00000026254
Prkx GeneProduct ensembl:ENSMUSG00000035725
Crkl GeneProduct ensembl:ENSMUSG00000006134
Col4a2 GeneProduct ensembl:ENSMUSG00000031503
Mapk3 GeneProduct ensembl:ENSMUSG00000063065
Pik3r3 GeneProduct ensembl:ENSMUSG00000028698
Exoc7 GeneProduct ensembl:ENSMUSG00000020792
Bcl2 GeneProduct ensembl:ENSMUSG00000057329
Bad GeneProduct ensembl:ENSMUSG00000024959
Pik3r1 GeneProduct ensembl:ENSMUSG00000041417
Col1a1 GeneProduct ensembl:ENSMUSG00000001506
Rheb GeneProduct ensembl:ENSMUSG00000028945
Cdkn1b GeneProduct ensembl:ENSMUSG00000003031
Prkar2a GeneProduct ensembl:ENSMUSG00000032601
Raf1 GeneProduct ensembl:ENSMUSG00000000441


  1. MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling. Kwon DN, Chang BS, Kim JH. Biomed Res Int. 2014;2014:236385. PubMed Europe PMC Scholia