Dysregulated miRNA targeting in insulin/PI3K-AKT signaling (WP3855)
This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.
AuthorsAAR&Co , Martina Summer-Kutmon , Kristina Hanspers , Eric Weitz , and Egon Willighagen
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Disease Ontologytype 2 diabetes mellitus glucose intolerance
Pathway Ontologyregulatory pathway
- MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling. Kwon DN, Chang BS, Kim JH. Biomed Res Int. 2014;2014:236385. PubMed Europe PMC Scholia