Triacylglyceride synthesis (WP325)

Homo sapiens

Triacylglyceride (or triglyceride) is a major component of skin oils, animal and vegetable fats, and supports the transfer of adipose and glucose between the liver and circulatory system. Triacylglyceride is synthesized from glycerol and three fatty acids. The terminal step of synthesis is performed by Diglyceride acyltransferase (DGAT).


Chris Evelo , Alex Pico , Kristina Hanspers , Adrien Defay , Jesse Vercoulen , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

triacylglycerol biosynthetic pathway


Label Type Compact URI Comment
Diacylglycerol Metabolite kegg.compound:C00165
Acyl dihydroxyacetone phosphate Metabolite kegg.compound:C03372
Fatty acyl CoA Metabolite chebi:37554
Fatty acyl CoA Metabolite chebi:37554
Glycerol Metabolite cas:56-81-5
Fatty acyl CoA Metabolite chebi:37554
Triacylglycerol Metabolite kegg.compound:C00422
Monoacylglycerol Metabolite kegg.compound:C01885
Phosphatidic acid Metabolite pubchem.compound:5460104
Dihydroxyacetone phosphate Metabolite cas:57-04-5
Lysophosphatidic acid Metabolite pubchem.compound:5497152
Dihydroxyacetone phosphate Metabolite hmdb:HMDB0001473
Glycerol-3-phosphate Metabolite kegg.compound:C00093
PPAP2B GeneProduct ncbigene:8613
GPD1 GeneProduct ncbigene:2819
DGAT2 GeneProduct ncbigene:84649
LIPF GeneProduct ncbigene:8513
AGPAT1 GeneProduct ncbigene:10554
PPAP2A GeneProduct ncbigene:8611
MOGAT1 GeneProduct ncbigene:116255
GNPAT GeneProduct ncbigene:8443
GK GeneProduct ncbigene:2710
PPAP2C GeneProduct ncbigene:8612
AGPAT2 GeneProduct ncbigene:10555
LPL GeneProduct ncbigene:4023
GPAM GeneProduct ncbigene:57678
MOGAT2 GeneProduct ncbigene:80168
PNPLA2 GeneProduct ncbigene:57104
AGPS GeneProduct ncbigene:8540
AGPAT5 GeneProduct ncbigene:55326
GK2 GeneProduct ncbigene:2712
DGAT1 GeneProduct ncbigene:8694
LIPC GeneProduct ncbigene:3990
MOGAT3 GeneProduct ncbigene:346606
AGPAT3 GeneProduct ncbigene:56894
LIPE GeneProduct ncbigene:3991
AGPAT4 GeneProduct ncbigene:56895