SREBP signaling (WP3194)

Bos taurus

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focusses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human. This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: [http://www.ncbi.nlm.nih.gov/pubmed/23516131 PubMed].

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

sterol regulatory element-binding protein signaling pathway sterol regulatory element-binding protein signaling pathway cholesterol biosynthetic pathway fatty acid biosynthetic pathway

Disease Ontology

obsolete hypercholesterolemia

Cell Type Ontology

hepatocyte

Participants

Label Type Compact URI Comment
Glucose Metabolite hmdb:HMDB0000122
PUFAs Metabolite chebi:26208 Inhibition of SREBP1 processing
Cholesterol Metabolite hmdb:HMDB0000067
UFAs Metabolite chebi:26208
Glutamine Metabolite hmdb:HMDB0000641
Oxysterols Metabolite chebi:53030
PRKACA GeneProduct ensembl:ENSBTAG00000006642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072062
SCAP GeneProduct ensembl:ENSBTAG00000015782 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114650
CDK8 GeneProduct ensembl:ENSBTAG00000016737 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132964
PRKAA2 GeneProduct ensembl:ENSBTAG00000018747 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162409
CATHL3 GeneProduct ensembl:ENSBTAG00000031599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164047
PRKAG2 GeneProduct ensembl:ENSBTAG00000002917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106617
AKT1 GeneProduct ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
AMFR GeneProduct ensembl:ENSBTAG00000003798 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159461
PRKAG3 GeneProduct ensembl:ENSBTAG00000013492 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115592
KPNB1 GeneProduct ensembl:ENSBTAG00000006586 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108424
SREBF2 GeneProduct ensembl:ENSBTAG00000014265 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121879
INSIG1 GeneProduct ensembl:ENSBTAG00000001592 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186480
LPIN1 GeneProduct ensembl:ENSBTAG00000007689 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134324
NR1H2 GeneProduct ensembl:ENSBTAG00000003264 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131408
NFYA GeneProduct ensembl:ENSBTAG00000009905 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001167
PRKAB2 GeneProduct ensembl:ENSBTAG00000014387 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131791
RNF139 GeneProduct ensembl:ENSBTAG00000020399 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170881
SREBF1 GeneProduct ensembl:ENSBTAG00000007884 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310
ATF6 GeneProduct ensembl:ENSBTAG00000005227 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118217
PRKAA1 GeneProduct ensembl:ENSBTAG00000000013 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132356
MBTPS1 GeneProduct ensembl:ENSBTAG00000010170 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140943
FGF21 GeneProduct ensembl:ENSBTAG00000011624 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105550
GSK3A GeneProduct ensembl:ENSBTAG00000020756 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105723
PRKAB1 GeneProduct ensembl:ENSBTAG00000005940 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111725
RBP4 GeneProduct ensembl:ENSBTAG00000000442 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138207
PRKAG1 GeneProduct ensembl:ENSBTAG00000014426 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181929
MTOR GeneProduct ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
HMGCR GeneProduct ensembl:ENSBTAG00000007840 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161
SIRT1 GeneProduct ensembl:ENSBTAG00000014023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717
INSIG2 GeneProduct ensembl:ENSBTAG00000002112 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125629
SAR1A GeneProduct ensembl:ENSBTAG00000016858 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079332
SAR1B GeneProduct ensembl:ENSBTAG00000021226 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152700
SEC23A GeneProduct ensembl:ENSBTAG00000003708 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100934
SEC23B GeneProduct ensembl:ENSBTAG00000018295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101310
SEC24A GeneProduct ensembl:ENSBTAG00000018322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113615
SEC24B GeneProduct ensembl:ENSBTAG00000010945 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138802
SEC24C GeneProduct ensembl:ENSBTAG00000002791 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176986
SEC24D GeneProduct ensembl:ENSBTAG00000003619 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150961
SEC13 GeneProduct ensembl:ENSBTAG00000017825 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157020
SEC31A GeneProduct ensembl:ENSBTAG00000020525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138674
SEC31B GeneProduct ensembl:ENSBTAG00000000090 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075826
MBTPS2 GeneProduct ensembl:ENSBTAG00000008183 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000012174
CREB1 GeneProduct ensembl:ENSBTAG00000005474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118260
SP1 GeneProduct ensembl:ENSBTAG00000003021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591
YY1 GeneProduct ensembl:ENSBTAG00000020819 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100811
PPARGC1B GeneProduct ensembl:ENSBTAG00000012943 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155846
MED15 GeneProduct ensembl:ENSBTAG00000018048 activator recruited cofactor (ARC)-mediator activator complex
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917
LSS GeneProduct ensembl:ENSBTAG00000018936 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160285
HMGCS1 GeneProduct ensembl:ENSBTAG00000011839 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972
MVD GeneProduct ensembl:ENSBTAG00000012059 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167508
IDI1 GeneProduct ensembl:ENSBTAG00000004075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067064
FDPS GeneProduct ensembl:ENSBTAG00000003948 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160752
FDFT1 GeneProduct ensembl:ENSBTAG00000012432 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079459
SQLE GeneProduct ensembl:ENSBTAG00000005498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104549
CYP51A1 GeneProduct ensembl:ENSBTAG00000001992 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630
LPL GeneProduct ensembl:ENSBTAG00000012855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175445
LDLR GeneProduct ensembl:ENSBTAG00000012314 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164
SCARB1 GeneProduct ensembl:ENSBTAG00000014269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073060
ACACA GeneProduct ensembl:ENSBTAG00000017567 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000278540
GPAM GeneProduct ensembl:ENSBTAG00000011917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119927
FASN GeneProduct ensembl:ENSBTAG00000015980 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169710
DBI GeneProduct ensembl:ENSBTAG00000009517 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155368
ACLY GeneProduct ensembl:ENSBTAG00000016740 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131473
MDH1 GeneProduct ensembl:ENSBTAG00000019295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000014641
PPARG GeneProduct ensembl:ENSBTAG00000001333 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132170
ACSS1 GeneProduct ensembl:ENSBTAG00000004281 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154930
SCD GeneProduct ensembl:ENSBTAG00000047957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099194

References

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  2. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. Sakai J, Nohturfft A, Goldstein JL, Brown MS. J Biol Chem. 1998 Mar 6;273(10):5785–93. PubMed Europe PMC Scholia
  3. Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. Bennett MK, Ngo TT, Athanikar JN, Rosenfeld JM, Osborne TF. J Biol Chem. 1999 May 7;274(19):13025–32. PubMed Europe PMC Scholia
  4. YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. Ericsson J, Usheva A, Edwards PA. J Biol Chem. 1999 May 14;274(20):14508–13. PubMed Europe PMC Scholia
  5. Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip. Nagoshi E, Imamoto N, Sato R, Yoneda Y. Mol Biol Cell. 1999 Jul;10(7):2221–33. PubMed Europe PMC Scholia
  6. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Brown MS, Goldstein JL. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11041–8. PubMed Europe PMC Scholia
  7. Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. Ye J, Davé UP, Grishin NV, Goldstein JL, Brown MS. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5123–8. PubMed Europe PMC Scholia
  8. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, et al. Genes Dev. 2001 May 15;15(10):1206–16. PubMed Europe PMC Scholia
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  10. ATF6 modulates SREBP2-mediated lipogenesis. Zeng L, Lu M, Mori K, Luo S, Lee AS, Zhu Y, et al. EMBO J. 2004 Feb 25;23(4):950–8. PubMed Europe PMC Scholia
  11. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, et al. J Clin Invest. 2004 Apr;113(8):1168–75. PubMed Europe PMC Scholia
  12. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11245–50. PubMed Europe PMC Scholia
  13. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, et al. Cell. 2005 Jan 28;120(2):261–73. PubMed Europe PMC Scholia
  14. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. Sun LP, Li L, Goldstein JL, Brown MS. J Biol Chem. 2005 Jul 15;280(28):26483–90. PubMed Europe PMC Scholia
  15. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Gong Y, Lee JN, Lee PCW, Goldstein JL, Brown MS, Ye J. Cell Metab. 2006 Jan;3(1):15–24. PubMed Europe PMC Scholia
  16. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, et al. Nature. 2006 Aug 10;442(7103):700–4. PubMed Europe PMC Scholia
  17. Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs. Dif N, Euthine V, Gonnet E, Laville M, Vidal H, Lefai E. Biochem J. 2006 Nov 15;400(1):179–88. PubMed Europe PMC Scholia
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  19. Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver. Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, et al. J Biol Chem. 2007 Apr 20;282(16):11687–95. PubMed Europe PMC Scholia
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  21. Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J. J Biol Chem. 2008 Nov 28;283(48):33772–83. PubMed Europe PMC Scholia
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  41. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, Zhou J, et al. J Clin Invest. 2012 Jul;122(7):2417–27. PubMed Europe PMC Scholia
  42. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16184–9. PubMed Europe PMC Scholia
  43. Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle. Defour A, Dessalle K, Castro Perez A, Poyot T, Castells J, Gallot YS, et al. PLoS One. 2012;7(9):e43490. PubMed Europe PMC Scholia
  44. Retinol binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-γ coactivator 1β-dependent pathway. Xia M, Liu Y, Guo H, Wang D, Wang Y, Ling W. Hepatology. 2013 Aug;58(2):564–75. PubMed Europe PMC Scholia
  45. A pathway approach to investigate the function and regulation of SREBPs. Daemen S, Kutmon M, Evelo CT. Genes Nutr. 2013 May;8(3):289–300. PubMed Europe PMC Scholia