Triglyceride biosynthesis (WP266)

Saccharomyces cerevisiae

Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannose-(inositol phosphate)2-ceramide (M(IP)2C)(CITS: [12069845]). In the yeast plasma membrane sphingolipids concentrate with ergosterol to form lipid rafts, specialized membrane microdomains implicated in a variety of cellular processes, including sorting of membrane proteins and lipids, as well as organizing and regulating signaling cascades (CITS: [12452424]). Intermediates in sphingolipid biosynthesis have been shown to play important roles as signaling molecules and growth regulators. Sphingolipid long chain bases (LCBs), dihydrosphingosine (DHS) and phytosphingosine (PHS), have been implicated as secondary messengers in signaling pathways that regulate heat stress response (CITS: [9405471])(CITS: [11967828]). Other intermediates, phytoceramide and long-chain base phosphates (LCBPs), have been shown to be components of the tightly-controlled ceramide/LCBP rheostat, which regulates cell growth (CITS: [12684378]). Since phosphoinositol-containing sphingolipids are unique to fungi, the sphingolipid biosynthesis pathway is considered a target for antifungal drugs (CITS: [9092515])(CITS: [15578972]). SOURCE: SGD pathways,


Meredith Braymer , Daniela Digles , Egon Willighagen , and Eric Weitz


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Saccharomyces cerevisiae



Pathway Ontology

triacylglycerol biosynthetic pathway


Label Type Compact URI Comment
acyl-CoA Metabolite chebi:17984
Coenzyme A Metabolite cas:64885-97-8
phosphate Metabolite cas:14265-44-2
CDP-choline Metabolite cas:987-78-0
SLC1 GeneProduct sgd:S000002210
DGA1 GeneProduct sgd:S000005771
CPT1 GeneProduct sgd:S000005074
ISC1 GeneProduct sgd:S000000821


  1. Synthesis, storage and degradation of neutral lipids in yeast. Czabany T, Athenstaedt K, Daum G. Biochim Biophys Acta. 2007 Mar;1771(3):299–309. PubMed Europe PMC Scholia