Triglyceride biosynthesis (WP266)

Saccharomyces cerevisiae

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Triacylglycerol (TAG) is the major lipid reserve in plants and animals. The assembly of TAG occurs in the endoplasmic reticulum (ER). Four consecutive reactions are catalyzed by ER membrane bound enzymes. The two intermediates, phosphatidate and 1,2-diacylglycerol, are also substrates for the synthesis of membrane lipids glycosylglycerides and phosphoglycerides. Thus, the last step in the pathway, catalyzed by diacylglycerol acyltransferase, is the only dedicated step in triacylglycerol synthesis. Source: https://pathway.yeastgenome.org/.

Authors

Meredith Braymer , Daniela Digles , Egon Willighagen , Eric Weitz , and Kristina Hanspers

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

classic metabolic pathway triacylglycerol biosynthetic pathway

Participants

Label Type Compact URI Comment
1,2-diacyl-sn-glycerol 3-phosphate Metabolite chebi:29089
Phosphate Metabolite chebi:43474
triacyl-sn-glycerol Metabolite chebi:64615
1-acyl-sn-glycero-3-phosphocholine Metabolite chebi:17504
1,2-diacyl-sn-glycerol Metabolite chebi:17815
Acyl-CoA Metabolite chebi:17984
1-acyl-sn-glycerol 3-phosphate Metabolite chebi:16975
H2O Metabolite chebi:15377
phosphatidylcholine Metabolite chebi:16110
sn-glycerol 3-phosphate Metabolite chebi:57597
COENZYME A Metabolite chebi:15346
SLC1 GeneProduct sgd:S000002210
DGA1 GeneProduct ensembl:YOR245C
SCT1 GeneProduct ensembl:YBL011W
PAH1 GeneProduct ensembl:YMR165C
GPT2 GeneProduct ensembl:YKR067W
DPP1 GeneProduct ensembl:YDR284C
LPP1 GeneProduct ensembl:YDR503C
LRO1 GeneProduct ensembl:YNR008W

References

  1. Synthesis, storage and degradation of neutral lipids in yeast. Czabany T, Athenstaedt K, Daum G. Biochim Biophys Acta. 2007 Mar;1771(3):299–309. PubMed Europe PMC Scholia
  2. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=NIL&object=TRIGLSYN-PWY