Male steroid hormones in cardiomyocyte energy metabolism (WP5320)

Homo sapiens

The effect of testosterone and Androstanedione on energy metabolism in cardiomyocytes.
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Authors

Isis Sampermans , Bhavana Kapalli , Andra Waagmeester , Egon Willighagen , Alex Pico , and Javier Millán Acosta

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: classic metabolic pathway

Participants

Label Type Compact Identifier Comment
progesterone Metabolite chebi:17026
Epiandrosterone Metabolite hmdb:HMDB0000365
DHEA Metabolite chebi:28689
Testosterone glucuronide Metabolite chebi:28835
Epietiocholanolone Metabolite hmdb:HMDB0000546
testosterone Metabolite chebi:17347
androsterone Metabolite wikidata:Q422469
Etiocholanolone Metabolite hmdb:HMDB0000490
3α-Androstane-diol Metabolite pubchem.compound:5879
Androstanedione Metabolite hmdb:HMDB0000053
3β-Androstane-diol Metabolite pubchem.compound:441302
5β-Dihydro-testosterone Metabolite pubchem.compound:11302
oestradiol Metabolite chebi:23965
Testosterone-sulfate Metabolite pubchem.compound:119207
3β-Eticholane-diol Metabolite pubchem.compound:247732
androstenediol Metabolite wikidata:Q2817108
cholesterol Metabolite chebi:16113
Androgen Receptor (AR) Metabolite hmdb:HMDB0001624
3α-Etiocholane-diol Metabolite pubchem.compound:5880
pregnenolone Metabolite chebi:16581
17a Hydroxypregnenolone Metabolite hmdb:HMDB0000363
Androstenedione Metabolite hmdb:HMDB0000053
estrone Metabolite chebi:17263
5α-Dihydro-testosterone Metabolite pubchem.compound:10635
HSD17B3 GeneProduct uniprot:P37058
HSD17B2 GeneProduct uniprot:P37059
SRD5A1/5α-reductase GeneProduct uniprot:P18405
AKR1C3 GeneProduct uniprot:A0A0A0MSS8
AKR1C3 GeneProduct uniprot:A0A0A0MSS8
3β-HSD2 GeneProduct uniprot:P26439
HSD3B1 GeneProduct uniprot:P14060
HSD3B2 GeneProduct uniprot:P26439
HSD3B2 GeneProduct ensembl:ENSG00000203859.10
HSD3B1 GeneProduct ensembl:ENSG00000203857.10
HSD17B3 GeneProduct uniprot:P37058
SRD5A2/5β-reductase GeneProduct uniprot:P31213
SRD5A1 GeneProduct ensembl:ENSG00000145545.12
SRD5A2 GeneProduct ensembl:ENSG00000277893.2
17β-HSD Protein uniprot:Q9BPX1
17β-HSD Protein uniprot:Q9BPX1
Aromatase Protein uniprot:P11511
HSD17B3 Protein uniprot:P37058
3α-HSD Protein uniprot:P80701
AKR1C3 Protein uniprot:A0A0A0MSS8
CYP17A1(17α-hydroxylase) Protein uniprot:P05093
17β-HSD Protein ena.embl:CHEMBL4234
Sulfotransferase Protein uniprot:P50225
3α-HSD Protein uniprot:P80701
HSD17B2 Protein uniprot:P37059
3β-HSD Protein uniprot:Q9N119
CYP17A1(C17,20-lyase) Protein uniprot:P05093
CYP11A1 Protein uniprot:P05108
Aromatase Protein uniprot:P11511
3β-HSD Protein uniprot:Q9N119
17β-HSD Protein uniprot:Q9BPX1
Glucuronosyl-transferase Protein uniprot:P22309
17β-HSD Protein uniprot:Q9BPX1
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References

  1. Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer. Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, et al. Sci Rep. 2013;3:1528. PubMed Europe PMC Scholia
  2. Androgen Physiology: Receptor and Metabolic Disorders. McEwan IJ, Brinkmann AO. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, et al., editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2021. PubMed Europe PMC Scholia
  3. Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Davey RA, Grossmann M. Clin Biochem Rev. 2016 Feb;37(1):3–15. PubMed Europe PMC Scholia
  4. Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes. Carbajal-García A, Reyes-García J, Montaño LM. Int J Endocrinol. 2020 Nov 12;2020:8849641. PubMed Europe PMC Scholia