Male steroid hormones in cardiomyocyte energy metabolism (WP5320)

Homo sapiens

The effect of testosterone and Androstanedione on energy metabolism in cardiomyocytes.


Isis Sampermans , Bhavana Kapalli , Andra Waagmeester , Egon Willighagen , Alex Pico , and Javier Millán Acosta


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Homo sapiens



Pathway Ontology

classic metabolic pathway


Label Type Compact URI Comment
progesterone Metabolite chebi:17026
Epiandrosterone Metabolite hmdb:HMDB0000365
DHEA Metabolite chebi:28689
Testosterone glucuronide Metabolite chebi:28835
Epietiocholanolone Metabolite hmdb:HMDB0000546
testosterone Metabolite chebi:17347
androsterone Metabolite wikidata:Q422469
Etiocholanolone Metabolite hmdb:HMDB0000490
3α-Androstane-diol Metabolite pubchem.compound:5879
Androstanedione Metabolite hmdb:HMDB0000053
3β-Androstane-diol Metabolite pubchem.compound:441302
5β-Dihydro-testosterone Metabolite pubchem.compound:11302
oestradiol Metabolite chebi:23965
Testosterone-sulfate Metabolite pubchem.compound:119207
3β-Eticholane-diol Metabolite pubchem.compound:247732
androstenediol Metabolite wikidata:Q2817108
cholesterol Metabolite chebi:16113
Androgen Receptor (AR) Metabolite hmdb:HMDB0001624
3α-Etiocholane-diol Metabolite pubchem.compound:5880
pregnenolone Metabolite chebi:16581
17a Hydroxypregnenolone Metabolite hmdb:HMDB0000363
Androstenedione Metabolite hmdb:HMDB0000053
estrone Metabolite chebi:17263
5α-Dihydro-testosterone Metabolite pubchem.compound:10635
HSD17B3 GeneProduct uniprot:P37058
HSD17B2 GeneProduct uniprot:P37059
SRD5A1/5α-reductase GeneProduct uniprot:P18405
AKR1C3 GeneProduct uniprot:A0A0A0MSS8
AKR1C3 GeneProduct uniprot:A0A0A0MSS8
3β-HSD2 GeneProduct uniprot:P26439
HSD3B1 GeneProduct uniprot:P14060
HSD3B2 GeneProduct uniprot:P26439
HSD3B2 GeneProduct ensembl:ENSG00000203859.10
HSD3B1 GeneProduct ensembl:ENSG00000203857.10
HSD17B3 GeneProduct uniprot:P37058
SRD5A2/5β-reductase GeneProduct uniprot:P31213
SRD5A1 GeneProduct ensembl:ENSG00000145545.12
SRD5A2 GeneProduct ensembl:ENSG00000277893.2
17β-HSD Protein uniprot:Q9BPX1
17β-HSD Protein uniprot:Q9BPX1
Aromatase Protein uniprot:P11511
HSD17B3 Protein uniprot:P37058
3α-HSD Protein uniprot:P80701
AKR1C3 Protein uniprot:A0A0A0MSS8
CYP17A1(17α-hydroxylase) Protein uniprot:P05093
17β-HSD Protein ena.embl:CHEMBL4234
Sulfotransferase Protein uniprot:P50225
3α-HSD Protein uniprot:P80701
HSD17B2 Protein uniprot:P37059
3β-HSD Protein uniprot:Q9N119
CYP17A1(C17,20-lyase) Protein uniprot:P05093
CYP11A1 Protein uniprot:P05108
Aromatase Protein uniprot:P11511
3β-HSD Protein uniprot:Q9N119
17β-HSD Protein uniprot:Q9BPX1
Glucuronosyl-transferase Protein uniprot:P22309
17β-HSD Protein uniprot:Q9BPX1


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  2. Androgen Physiology: Receptor and Metabolic Disorders. McEwan IJ, Brinkmann AO. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, et al., editors. Endotext. South Dartmouth (MA):, Inc.; 2021. PubMed Europe PMC Scholia
  3. Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Davey RA, Grossmann M. Clin Biochem Rev. 2016 Feb;37(1):3–15. PubMed Europe PMC Scholia
  4. Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes. Carbajal-García A, Reyes-García J, Montaño LM. Int J Endocrinol. 2020 Nov 12;2020:8849641. PubMed Europe PMC Scholia