Fatty acid omega-oxidation (WP206)

Homo sapiens

Dodecanoate, or lauric acid, is found in the fats and oils of both plants and animals, especially coconut and palm kernel oil. This pathway shows the degradation of dodecanoate leading to beta oxidation. Created by Magali Jaillard, Marijke Vermeer, Michiel Adrieans, Ron Schormans and Chris Evelo. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP206 CPTAC Assay Portal]


Chris Evelo , Michiel Adriaens , Alex Pico , Christine Chichester , Egon Willighagen , Denise Slenter , Kristina Hanspers , and Eric Weitz


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Homo sapiens



Disease Ontology

lipid metabolism disorder

Pathway Ontology

fatty acid degradation pathway fatty acid omega degradation pathway fatty acid metabolic pathway


Label Type Compact URI Comment
HO-CH-(CH2)10-COO- Metabolite chebi:39567
CH3-(CH2)10-COO- Metabolite chebi:30805
-OOC-(CH2)10-COO- Metabolite chebi:76273
HOC-(CH2)10-COO- Metabolite pubchem.compound:3084276 14-hydroxytetradecanoic acid
ADH1C GeneProduct ncbigene:126
ALDH1A1 GeneProduct ncbigene:216
ADH7 GeneProduct ncbigene:131
CYP2E1 GeneProduct ncbigene:1571
ADH1B GeneProduct ncbigene:125
CYP3A4 GeneProduct ncbigene:1576
CYP2D6 GeneProduct ncbigene:1565
CYP1A1 GeneProduct ncbigene:1543
ADH6 GeneProduct ncbigene:130
ALDH2 GeneProduct ncbigene:217
ADH4 GeneProduct ncbigene:127
ADH1A GeneProduct ncbigene:124
CYP4A11 GeneProduct ncbigene:1579
CYP1A2 GeneProduct ncbigene:1544
CYP2A6 GeneProduct ncbigene:1548