Inflammatory response pathway (WP453)

Homo sapiens

Inflammation is a protective response of cells to pathogens, infection or tissue damage. It involves the coordinated communication of different immune cells and blood vessels through an intricate cascade of molecular signals. Inflammation can cause fever, cardiovascular pathology, allergy anaphylaxis, fibrosis, autoimmunity, etc. The inflammatory response has four phases: inflammatory inducers (infection or tissue damage), inflammatory sensors (mast cells and macrophages), inflammatory mediators (cytokines, chemokines, etc.) and the tissues that are affected. Each phase has many options that are triggered based on the type pathogen introduced. In addition, chronic inflammatory conditions, where an inducer is not well defined, are becoming more common. These conditions are of particular interest because they coincide with other diseases such as obesity, type 2 diabetes, atherosclerosis, neurodegenerative diseases and cancer. [] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Nick Fidelman , Kristina Hanspers , Zahra Roudbari , Denise Slenter , and Eric Weitz


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Homo sapiens



Cell Type Ontology

B cell fibroblast

Pathway Ontology

inflammatory response pathway


Label Type Compact URI Comment
IGHA2 GeneProduct ensembl:ENSG00000211890
IGHA1 GeneProduct ensembl:ENSG00000211895
CD86 GeneProduct ncbigene:942
TNFRSF1B GeneProduct ncbigene:7133
LAMB2 GeneProduct ncbigene:3913
IFNG GeneProduct ncbigene:3458
IGHM GeneProduct ncbigene:3507
THBS3 GeneProduct ncbigene:7059
VTN GeneProduct ncbigene:7448
IL2 GeneProduct ncbigene:3558
IL4R GeneProduct ncbigene:3566
IL2RB GeneProduct ncbigene:3560
LCK GeneProduct ncbigene:3932
LAMB1 GeneProduct ncbigene:3912
IL2RG GeneProduct ncbigene:3561
IL4 GeneProduct ncbigene:3565
COL3A1 GeneProduct ncbigene:1281
CD40 GeneProduct ncbigene:958
COL1A1 GeneProduct ncbigene:1277
LAMC2 GeneProduct ncbigene:3918
COL1A2 GeneProduct ncbigene:1278
CD28 GeneProduct ncbigene:940
CD40LG GeneProduct ncbigene:959
TNFRSF1A GeneProduct ncbigene:7132
FN1 GeneProduct ncbigene:2335
CD80 GeneProduct ncbigene:941
IL2RA GeneProduct ncbigene:3559
LAMC1 GeneProduct ncbigene:3915
ZAP70 GeneProduct ncbigene:7535
LAMA5 GeneProduct ncbigene:3911
THBS1 GeneProduct ncbigene:7057
IL5 GeneProduct ncbigene:3567
IL5RA GeneProduct ncbigene:3568


  1. Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. Monahan J, Siegel N, Keith R, Caparon M, Christine L, Compton R, et al. J Immunol. 1997 Oct 15;159(8):4024–34. PubMed Europe PMC Scholia
  2. Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay. Greisenegger S, Zehetmayer S, Bauer P, Endler G, Ferrari J, Lang W, et al. Clin Chem. 2009 Jan;55(1):134–8. PubMed Europe PMC Scholia