Isoglobo series sphingolipids (WP5311)
Homo sapiens
Isoglobo pathway in its entirety from [https://www.lipidmaps.org/resources/sphingomap SphinGOMAP]. Solid conversion arrows are documented according to Sphingomap. Dotted conversions are hypothetical, either not occurring or undocumented (Sphingomap details all possible permutations of a pathway to the final glycolipid). Numbers represent the sphingomap IDs, to be converted. Metabolites coloured red are not yet in LIPIDMAPS Metabolites with a dotted box are hypothetical. These may or may not exist on the pathway to the final product as several different routes could occur.
Authors
Conroy lipids , Egon Willighagen , Andra Waagmeester , and Denise SlenterActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
sphingolipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| iGB5 | Metabolite | lipidmaps:LMSP0506AS00 | S_id=354Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer |
| GalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AK00 | S_id 424ECO:0008028 |
| Galalpha1-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BA00 | S_id 381ECO:0008028 |
| iGB4 | Metabolite | lipidmaps:LMSP0506AX00 | s_id 377 |
| Cytolipin R | Metabolite | lipidmaps:LMSP0506AR00 | s_id 353 |
| Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AY00 | S_id 378 |
| iGB3 | Metabolite | lipidmaps:LMSP0506AQ00 | s_id 11Galα1–4Galβ1–4Glcβ1Cer |
| NeuAcα2-IGB5 | Metabolite | lipidmaps:LMSP0601GL00 | s_id 401NeuAcα2-6Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer |
| NeuAcalpha2-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GK00 | S_id 379 |
| Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AM00 | S_id 427ECO:0008028 |
| HSO3-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0602AO00 | S_id 415 |
| LacCer | Metabolite | chebi:17950 | |
| Galalpha1-3(Fucalpha1-2)Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BC00 | S_id 383 |
| HSO3-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0602AP00 | S_id 400 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AL00 | S_id 426ECO:0008028 |
| Forssman-like iGb4 | Metabolite | lipidmaps:LMSP0506AD00 | S_id 398 |
| Fucalpha1-2Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BB00 | S_id 382ECO:0008028 |
| NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GW00 | S_id 397ECO:0008028 |
| Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GS00 | ECO:0008028 |
| Fucalpha1-3GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BI00 | S_id 395ECO:0008028 |
| Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BH00 | S_id 394ECO:0008028 |
| Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AW00 | S_id 375ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GQ00 | S_id 420ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AJ00 | S_id 422ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AI00 | S_id 421ECO:0008028 |
| NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GV00 | S_id 376ECO:0008028 |
| NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GH00 | s_idECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GR00 | S_id 423ECO:0008028 |
| NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GI00 | S_id 371Type your comment here |
| Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BJ00 | S_id 396ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AH00 | S_ID 416ECO:0008028 |
| NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6(GalNAcbeta1-3Galalpha1-3)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GX00 | S_id 399ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GP00 | S_id 419ECO:0008028 |
| GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0601GO00 | S_id 418 |
| Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AN00 | S_id 429ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AO00 | S_id 430ECO:0008028 |
| GalNAcbeta1-3Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BE00 | S_id 385 |
| Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AU00 | S_id 373ECO:0008028 |
| Fucalpha1-3GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AV00 | s_id 374ECO:0008028 |
| GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BG00 | S-id 393ECO:0008028 |
| Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AT00 | S_id 372ECO:0008028 |
| Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BF00 | S_id 392ECO:0008028 |
| Fucalpha1-2Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AA00 | Sphingolipid ID 411 |
| Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506BD00 | S-id 384ECO:0008028 |
| Galalpha1-3(Fucalpha1-2)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AZ00 | s_id 380 |
| Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer | Metabolite | lipidmaps:LMSP0506AP00 | ECO:0008028 |
| β3GalT-V | Protein | uniprot:Q9Y2C3 | AKA β3-Galactosyltransferase (β3GalT) , B3GALT5Annotation based on Book chapter, DOI: 10.1007/978-4-431-67877-9_6 |
References
- SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia
- Fold-recognition and comparative modeling of human beta3GalT I, II, IV, V and VI and beta3GalNAcT I: prediction of residues conferring acceptor substrate specificity. Patel RY, Balaji PV. J Mol Graph Model. 2007 Jul;26(1):255–68. PubMed Europe PMC Scholia
- Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Merrill AH Jr. Chem Rev. 2011 Oct 12;111(10):6387–422. PubMed Europe PMC Scholia