Isoglobo series sphingolipids (WP5311)

Homo sapiens

Isoglobo pathway in its entirety from [https://www.lipidmaps.org/resources/sphingomap SphinGOMAP]. Solid conversion arrows are documented according to Sphingomap. Dotted conversions are hypothetical, either not occurring or undocumented (Sphingomap details all possible permutations of a pathway to the final glycolipid). Numbers represent the sphingomap IDs, to be converted. Metabolites coloured red are not yet in LIPIDMAPS Metabolites with a dotted box are hypothetical. These may or may not exist on the pathway to the final product as several different routes could occur.

Authors

Conroy lipids , Egon Willighagen , Andra Waagmeester , Denise Slenter , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

lipid metabolic pathway sphingolipid metabolic pathway

Participants

Label Type Compact URI Comment
iGB5 Metabolite lipidmaps:LMSP0506AS00 S_id=354
Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer
GalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AK00 S_id 424
ECO:0008028
Galalpha1-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BA00 S_id 381
ECO:0008028
iGB4 Metabolite lipidmaps:LMSP0506AX00 s_id 377
Cytolipin R Metabolite lipidmaps:LMSP0506AR00 s_id 353
Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AY00 S_id 378
iGB3 Metabolite lipidmaps:LMSP0506AQ00 s_id 11
Galα1–4Galβ1–4Glcβ1Cer
NeuAcα2-IGB5 Metabolite lipidmaps:LMSP0601GL00 s_id 401
NeuAcα2-6Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glcβ-Cer
NeuAcalpha2-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GK00 S_id 379
Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AM00 S_id 427
ECO:0008028
HSO3-3Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0602AO00 S_id 415
LacCer Metabolite chebi:17950
Galalpha1-3(Fucalpha1-2)Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BC00 S_id 383
HSO3-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0602AP00 S_id 400
GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AL00 S_id 426
ECO:0008028
Forssman-like iGb4 Metabolite lipidmaps:LMSP0506AD00 S_id 398
Fucalpha1-2Galbeta1-3GalNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BB00 S_id 382
ECO:0008028
NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GW00 S_id 397
ECO:0008028
Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GS00 ECO:0008028
Fucalpha1-3GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BI00 S_id 395
ECO:0008028
Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BH00 S_id 394
ECO:0008028
Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AW00 S_id 375
ECO:0008028
GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GQ00 S_id 420
ECO:0008028
GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AJ00 S_id 422
ECO:0008028
GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AI00 S_id 421
ECO:0008028
NeuAcalpha1-3Galbeta1-4GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GV00 S_id 376
ECO:0008028
NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GH00 s_id
ECO:0008028
GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GR00 S_id 423
ECO:0008028
NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GI00 S_id 371
Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BJ00 S_id 396
ECO:0008028
GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(GalNAcbeta1-4Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AH00 S_ID 416
ECO:0008028
NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6(GalNAcbeta1-3Galalpha1-3)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GX00 S_id 399
ECO:0008028
GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GP00 S_id 419
ECO:0008028
GalNAcalpha1-3GalNAcbeta1-3Galalpha1-3(NeuAcalpha2-3(GalNAcbeta1-4)Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0601GO00 S_id 418
Galalpha1-3(Galbeta1-4GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AN00 S_id 429
ECO:0008028
GalNAcbeta1-3Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AO00 S_id 430
ECO:0008028
GalNAcbeta1-3Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BE00 S_id 385
Galbeta1-4GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AU00 S_id 373
ECO:0008028
Fucalpha1-3GlcNAcbeta1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AV00 s_id 374
ECO:0008028
GlcNAcbeta1-3Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BG00 S-id 393
ECO:0008028
Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AT00 S_id 372
ECO:0008028
Galalpha1-3(GalNAcbeta1-4)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BF00 S_id 392
ECO:0008028
Fucalpha1-2Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AA00 Sphingolipid ID 411
Galalpha1-3Galalpha1-3Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506BD00 S-id 384
ECO:0008028
Galalpha1-3(Fucalpha1-2)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AZ00 s_id 380
Galalpha1-3(GlcNAcbeta1-6)Galbeta1-4Glcbeta-Cer Metabolite lipidmaps:LMSP0506AP00 ECO:0008028
β3GalT-V Protein uniprot:Q9Y2C3 AKA β3-Galactosyltransferase (β3GalT) , B3GALT5
Annotation based on Book chapter, DOI: 10.1007/978-4-431-67877-9_6

References

  1. SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia
  2. Fold-recognition and comparative modeling of human beta3GalT I, II, IV, V and VI and beta3GalNAcT I: prediction of residues conferring acceptor substrate specificity. Patel RY, Balaji PV. J Mol Graph Model. 2007 Jul;26(1):255–68. PubMed Europe PMC Scholia
  3. Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Merrill AH Jr. Chem Rev. 2011 Oct 12;111(10):6387–422. PubMed Europe PMC Scholia