Nifedipine activity (WP259)

Homo sapiens

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Nifedipine (brand names Adalat, Nifediac, Cordipin, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal’s angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud’s phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers. Source: Wikipedia.

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Authors

Robatwiki , Alex Pico , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

nifedipine drug pathway

Disease Ontology

heart disease hypertension

Participants
Query Drugst.One

Label Type Compact URI Comment
Nifedipine Metabolite chebi:7565
Cholesterol Metabolite chebi:16113
NO Metabolite hmdb:HMDB0003378
PCNA GeneProduct ncbigene:5111
MAP2K1 GeneProduct ncbigene:5604
SOD GeneProduct ncbigene:6647
BDKRB2 GeneProduct ncbigene:624
CYP3A4 GeneProduct ncbigene:1576
PKC GeneProduct ncbigene:50818
KDR/FLK1 GeneProduct ncbigene:3791
MAPK1 GeneProduct ncbigene:5594
PTK2B GeneProduct ncbigene:2185
VEGF Protein uniprot:VEGF

References

  1. Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2. Hirata A, Igarashi M, Yamaguchi H, Suwabe A, Daimon M, Kato T, et al. Br J Pharmacol. 2000 Dec;131(8):1521–30. PubMed Europe PMC Scholia