G13 signaling (WP524)

Homo sapiens

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP524 CPTAC Assay Portal]


Anita Chow , Kushidat , Kristina Hanspers , Thomas Kelder , Alex Pico , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway


Label Type Compact URI Comment
RTKN GeneProduct ncbigene:6242
PKN1 GeneProduct ncbigene:5585
CFL2 GeneProduct ncbigene:1073
RHPN2 GeneProduct ncbigene:85415
RHOA GeneProduct ncbigene:387
PFN1 GeneProduct ncbigene:5216
ARHGEF1 GeneProduct ncbigene:9138
CYFIP1 GeneProduct ncbigene:23191
GNA13 GeneProduct ncbigene:10672
IQGAP2 GeneProduct ncbigene:10788
IQGAP1 GeneProduct ncbigene:8826
PIK3CD GeneProduct ncbigene:5293 P42338
ARHGDIB GeneProduct ncbigene:397
PIK3CB GeneProduct ncbigene:5291
SH3MD2 GeneProduct ncbigene:57630 Posh
LIMK1 GeneProduct ncbigene:3984
MYBPH GeneProduct ncbigene:4608
RAC1 GeneProduct ncbigene:5879
TNK2 GeneProduct ncbigene:10188 S33596
PAK3 GeneProduct ncbigene:5063
PIP5K2A GeneProduct ncbigene:5305
MAPK10 GeneProduct ncbigene:5602
CALM1 GeneProduct ncbigene:801
WASL GeneProduct ncbigene:8976
PIK3R2 GeneProduct ncbigene:5296
PPP1CB GeneProduct ncbigene:5500
WAS GeneProduct ncbigene:7454
MAP3K4 GeneProduct ncbigene:4216
MYL1 GeneProduct ncbigene:4632
CIT GeneProduct ncbigene:11113
ARHGDIG GeneProduct ncbigene:398
ROCK1 GeneProduct ncbigene:6093 S69211
DIAPH1 GeneProduct ncbigene:1729
PIK3CA GeneProduct ncbigene:5290
CDC42 GeneProduct ncbigene:998
RPS6KB1 GeneProduct ncbigene:6198 A41687
ROCK2 GeneProduct ncbigene:9475 BAA31594
CFL1 GeneProduct ncbigene:1072


  1. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia