Hepatocyte growth factor receptor signaling (WP1046)

Bos taurus

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Authors

Martina Summer-Kutmon , Eric Weitz , and Denise Slenter

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Cell Type Ontology

hepatocyte

Pathway Ontology

Rho/Rac/Cdc42 mediated signaling pathway scatter factor/hepatocyte growth factor signaling pathway

Participants

Label Type Compact URI Comment
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
PTPN11 GeneProduct ensembl:ENSBTAG00000002048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
ELK1 GeneProduct ensembl:ENSBTAG00000015817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
MAP4K1 GeneProduct ensembl:ENSBTAG00000021145 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184
PXN GeneProduct ensembl:ENSBTAG00000018108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PAK1 GeneProduct ensembl:ENSBTAG00000010191 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
GRB2 GeneProduct ensembl:ENSBTAG00000004736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
C-MET GeneProduct ensembl:ENSBTAG00000006161 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233
PTK2B GeneProduct ensembl:ENSBTAG00000005958 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
SRC GeneProduct ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
RAP1B GeneProduct ensembl:ENSBTAG00000008967 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
CRKL GeneProduct ensembl:ENSBTAG00000045548 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399
GAB1 GeneProduct ensembl:ENSBTAG00000002813 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2549
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
STAT3 GeneProduct ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
CRK GeneProduct ensembl:ENSBTAG00000005665 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
PTEN GeneProduct ensembl:ENSBTAG00000009498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
PTK2 GeneProduct ensembl:ENSBTAG00000009578 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
RAPGEF1 GeneProduct ensembl:ENSBTAG00000020791 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889
RASA1 GeneProduct ensembl:ENSBTAG00000009565 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
RAP1A GeneProduct ensembl:ENSBTAG00000014710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
ITGB1 GeneProduct ensembl:ENSBTAG00000015910 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
DOCK1 GeneProduct ensembl:ENSBTAG00000031890 Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793
HGF GeneProduct ensembl:ENSBTAG00000017664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082
ITGA1 GeneProduct ensembl:ENSBTAG00000016525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3672
SOS1 GeneProduct ensembl:ENSBTAG00000011643 Son of sevenless homolog 1 (Drosophila) (predicted)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654

References

  1. An overview of the c-MET signaling pathway. Organ SL, Tsao MS. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7–19. PubMed Europe PMC Scholia