Genome Biology. 11:R3."> Wnt signaling pathway (WP980) - Bos taurus | WikiPathways

Wnt signaling pathway (WP980)

Bos taurus

WNT signal, through the canonical pathway, controls cell fate determination and through the non-canonical pathway controls cell movement and tissue polarity. The name "wnt" is a fusion of two terms, wg derived from the Drosophila gene wingless (wg) and int derived from the proto-oncogene integration-1, which is the mammalian homolog of wg. ß-catenin is the key regulated effector of Wnt, involved in canonical signaling . Free ß-catenin is bound by a multiprotein "destruction complex". The ß-catenin destruction complex is comprised of ß-catenin, scaffold proteins (APC, AXIN) and serine/threonine kinases that phosphorylate ß-catenin casein kinase 1 (CSNK1A1, CSNK1D, CSNK1E, CSNK1G1) and GSK3B. The sequential phosphorylation of ß-catenin by casein kinase 1 and GSK3 is recognised by an SCF-class E3-ubiquitin ligase, which targets it for polyubiquitination and proteosomal destruction. Canonical WNT signals are transduced through a two-part receptor, a seven-transmembrane Frizzled (FZD) and low density lipoprotein receptor-related protein 5/6 (LRP5/LRP6) to a ß-catenin (CTNNB1) signaling cascade. On recruitment of deshevelled (DVL1) to FZD and AXIN to LRP6, ß-catenin destruction complex disassembles leading to its stabilization and nuclear accumulation. Nuclear ß-catenin binds to T-cell factor/lymphoid enhancer factor (TCF/LEF) family of transcription factors and Legless family docking protein, BCL9. These activate the transcription of Wnt target genes CCND1, MYC. Non-canonical WNT signaling diverges downstream after being transduced through FZD family receptors and co-receptors, ROR2 and RYK. This pathway does not involve ß-catenin-mediated gene expression. Small G proteins such as RAC1, RHOA and downstream effectors of RAC including JNK are DVL-dependant effector molecules of the non-canonical pathway. These have been implicated in cytoskeletal rearrangement, dendrite growth and control of cell polarity and orientation. Nemo-like kinase (NLK) and nuclear factor of activated T cells (NFAT) are Ca2+-dependant effectors of the non-canonical pathway. NLK inhibits canonical pathway by phosphorylation of TCF/LEF family transcription factors. NFAT transcription factor is implicated in convergent extension during early embryogenesis and carcinogenic metastasis. Please access this pathway at [http://www.netpath.org/netslim/wnt_pathway.html NetSlim] database. If you use this pathway, please cite the following paper: Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Authors

Thomas Kelder , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

Wnt signaling, canonical pathway Wnt signaling pathway

Participants

Label Type Compact URI Comment
DVL3 Protein ensembl:ENSBTAG00000019336 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
AKT1 Protein ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
FRAT1 Protein ensembl:ENSBTAG00000007956 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10023
LRP6 Protein ensembl:ENSBTAG00000011761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4040
MAPK1 Protein ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
CSNK1E Protein ensembl:ENSBTAG00000047582 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1454
AXIN1 Protein ensembl:ENSBTAG00000016577 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
ARRB2 Protein ensembl:ENSBTAG00000035587 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:409
TCF3 Protein ensembl:ENSBTAG00000008695 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6929
GCKR Protein ensembl:ENSBTAG00000031302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2646
DVL1 Protein ensembl:ENSBTAG00000010696 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
RHOA Protein ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
CSNK1D Protein ensembl:ENSBTAG00000019986 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1453
CSNK1G1 Protein ensembl:ENSBTAG00000016823 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53944
LEF1 Protein ensembl:ENSBTAG00000006844 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176
CTBP1 Protein ensembl:ENSBTAG00000008480 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1487
CTNNB1 Protein ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
CCND1 Protein ensembl:ENSBTAG00000017514 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
PI4K2A Protein ensembl:ENSBTAG00000002010 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55361
APC Protein ensembl:ENSBTAG00000018852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
BCL9 Protein ensembl:ENSBTAG00000002422 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:607
CDK6 Protein ensembl:ENSBTAG00000044023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021
PRKCA Protein ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
RYK Protein ensembl:ENSBTAG00000016999 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6259
GSK3A Protein ensembl:ENSBTAG00000020756 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2931
TSC1 Protein ensembl:ENSBTAG00000005190 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7248
MAP3K7 Protein ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
LRP5 Protein ensembl:ENSBTAG00000005903 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4041
RAC1 Protein ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
PIP5K1B Protein ensembl:ENSBTAG00000009917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8395
PPARG Protein ensembl:ENSBTAG00000001333 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5468
PRKCB Protein ensembl:ENSBTAG00000020921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
DVL2 Protein ensembl:ENSBTAG00000003075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
TCFL2 Protein ensembl:ENSBTAG00000021574 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6934
PRKCG Protein ensembl:ENSBTAG00000013550 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
NFATC2 Protein ensembl:ENSBTAG00000018270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4773
MTOR Protein ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
ROR1 Protein ensembl:ENSBTAG00000012312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4919
SOX1 Protein ensembl:ENSBTAG00000038272 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6656
TCF7L2 Protein ensembl:ENSBTAG00000016462 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6925
GSK3B Protein ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
ROR2 Protein ensembl:ENSBTAG00000005092 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4920
MAPK9 Protein ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MAPK8 Protein ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
TSC2 Protein ensembl:ENSBTAG00000020617 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7249
NLK Protein ensembl:ENSBTAG00000014825 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51701

References

  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia