4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression (WP3879)

Homo sapiens

This pathway is modeled after Figure 7 in the article ''Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids'' (See Bibliography). Several anticancer agents up-regulate expression of p27, a cyclin-dpendent kinase inhibitor that blocks the transition from G1 to S phase. The pathways used by the anticancer agents (retinoic acids, 4-hydroxytamoxifen, dexamethasone) are shown above from human breast cancer cells.


AAR&Co , Kristina Hanspers , Egon Willighagen , Alex Pico , Andika Tan , Anders Riutta , Friederike Ehrhart , and Eric Weitz


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Homo sapiens




Disease Ontology

cancer breast cancer

Pathway Ontology

breast cancer pathway cancer pathway


Label Type Compact URI Comment
Triciribine Metabolite pubchem.compound:65399
LY 294, 002 Metabolite pubchem.compound:3973
SB202190 Metabolite pubchem.compound:5353940
Rotenone Metabolite pubchem.compound:6758
PD98059 Metabolite pubchem.compound:4713
AICA ribosidecompound C Metabolite pubchem.compound:17513
ERK inhibitor I Metabolite pubchem.compound:3377241
Retinoic acids? Metabolite hmdb:HMDB0001852
NSC119889 Metabolite pubchem.compound:274104
4-Hydroxytamoxifen Metabolite pubchem.compound:449459
Dexamethasone Metabolite pubchem.compound:5743
MNK1 GeneProduct ensembl:ENSG00000079277
eIF4E GeneProduct ensembl:ENSG00000151247
AMPK GeneProduct uniprot:Q13131
MKK6 GeneProduct ensembl:ENSG00000108984
Raf GeneProduct ensembl:ENSG00000132155
Mlk3 GeneProduct ensembl:ENSG00000173327
MEK2 GeneProduct ensembl:ENSG00000126934
AKT GeneProduct ensembl:ENSG00000142208
p38MAPK GeneProduct ensembl:ENSG00000197442
MEK1 GeneProduct ensembl:ENSG00000169032
PBK GeneProduct ensembl:ENSG00000168078
MNK2 GeneProduct ensembl:ENSG00000099875
ERK2 GeneProduct ensembl:ENSG00000100030
TSC1 GeneProduct hgnc.symbol:TSC1
ERK1 GeneProduct ensembl:ENSG00000102882
MKK3 GeneProduct ensembl:ENSG00000034152
mTOR GeneProduct ensembl:ENSG00000198793
EIF4EBP1 GeneProduct ensembl:ENSG00000187840
TSC2 GeneProduct hgnc.symbol:TSC2
PIK3CA GeneProduct hgnc.symbol:PIK3CA
PIK3CB GeneProduct hgnc.symbol:PIK3CB
PIK3CD GeneProduct hgnc.symbol:PIK3CD
PIK3R1 GeneProduct hgnc.symbol:PIK3R1
PIK3R2 GeneProduct hgnc.symbol:PIK3R2
PIK3R3 GeneProduct hgnc.symbol:PIK3R3


  1. Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids. Eto I. Cancer Cell Int. 2010 Feb 19;10:3. PubMed Europe PMC Scholia