4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression (WP3879)
Homo sapiens
This pathway is modeled after Figure 7 in the article ''Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids'' (See Bibliography). Several anticancer agents up-regulate expression of p27, a cyclin-dpendent kinase inhibitor that blocks the transition from G1 to S phase. The pathways used by the anticancer agents (retinoic acids, 4-hydroxytamoxifen, dexamethasone) are shown above from human breast cancer cells.
Authors
AAR&Co , Kristina Hanspers , Egon Willighagen , Alex Pico , Andika Tan , Anders Riutta , Friederike Ehrhart , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
CPTACAnnotations
Disease Ontology
cancer breast cancerPathway Ontology
breast cancer pathway cancer pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Triciribine | Metabolite | pubchem.compound:65399 | |
| LY 294, 002 | Metabolite | pubchem.compound:3973 | |
| SB202190 | Metabolite | pubchem.compound:5353940 | |
| Rotenone | Metabolite | pubchem.compound:6758 | |
| PD98059 | Metabolite | pubchem.compound:4713 | |
| AICA ribosidecompound C | Metabolite | pubchem.compound:17513 | |
| ERK inhibitor I | Metabolite | pubchem.compound:3377241 | |
| Retinoic acids? | Metabolite | hmdb:HMDB0001852 | |
| NSC119889 | Metabolite | pubchem.compound:274104 | |
| 4-Hydroxytamoxifen | Metabolite | pubchem.compound:449459 | |
| Dexamethasone | Metabolite | pubchem.compound:5743 | |
| MNK1 | GeneProduct | ensembl:ENSG00000079277 | |
| eIF4E | GeneProduct | ensembl:ENSG00000151247 | |
| AMPK | GeneProduct | uniprot:Q13131 | |
| MKK6 | GeneProduct | ensembl:ENSG00000108984 | |
| Raf | GeneProduct | ensembl:ENSG00000132155 | |
| Mlk3 | GeneProduct | ensembl:ENSG00000173327 | |
| MEK2 | GeneProduct | ensembl:ENSG00000126934 | |
| AKT | GeneProduct | ensembl:ENSG00000142208 | |
| p38MAPK | GeneProduct | ensembl:ENSG00000197442 | |
| MEK1 | GeneProduct | ensembl:ENSG00000169032 | |
| PBK | GeneProduct | ensembl:ENSG00000168078 | |
| MNK2 | GeneProduct | ensembl:ENSG00000099875 | |
| ERK2 | GeneProduct | ensembl:ENSG00000100030 | |
| TSC1 | GeneProduct | hgnc.symbol:TSC1 | |
| ERK1 | GeneProduct | ensembl:ENSG00000102882 | |
| MKK3 | GeneProduct | ensembl:ENSG00000034152 | |
| mTOR | GeneProduct | ensembl:ENSG00000198793 | |
| EIF4EBP1 | GeneProduct | ensembl:ENSG00000187840 | |
| TSC2 | GeneProduct | hgnc.symbol:TSC2 | |
| PIK3CA | GeneProduct | hgnc.symbol:PIK3CA | |
| PIK3CB | GeneProduct | hgnc.symbol:PIK3CB | |
| PIK3CD | GeneProduct | hgnc.symbol:PIK3CD | |
| PIK3R1 | GeneProduct | hgnc.symbol:PIK3R1 | |
| PIK3R2 | GeneProduct | hgnc.symbol:PIK3R2 | |
| PIK3R3 | GeneProduct | hgnc.symbol:PIK3R3 |
References
- Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids. Eto I. Cancer Cell Int. 2010 Feb 19;10:3. PubMed Europe PMC Scholia