Artemisinin inhibition of uveal melanoma (WP5441)

Homo sapiens

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Farhan et al. (2021) note: "By acting in PI3K/AKT/mTOR, a pathway with recognized importance in cancer, artemisinin was shown to be able to impair the migration, invasion, and proliferation of UM cells." Triangles indicate an increase or decrease in the adjacent entity. This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8684509__OMCL2021-9911537.012.html.

Authors

Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

uveal cancer melanoma

Pathway Ontology

drug pathway phosphatidylinositol 3-kinase-Akt signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Artemisinin Metabolite chebi:223316
Receptor tyrosine kinase GeneProduct eccode:2.7.10.1
PI3K GeneProduct eccode:2.7.1.137
MTOR GeneProduct ensembl:ENSG00000198793
AKT1 GeneProduct ensembl:ENSG00000142208
AKT2 GeneProduct ensembl:ENSG00000105221
AKT3 GeneProduct ensembl:ENSG00000117020

References

  1. Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway. Farhan M, Silva M, Xingan X, Zhou Z, Zheng W. Oxid Med Cell Longev. 2021 Dec 11;2021:9911537. PubMed Europe PMC Scholia