TGF-beta signaling pathway (WP113)

Mus musculus

The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: [ WikiPedia]). Also see: [ TGF-beta receptor signaling] at the NCI-Nature pathway interaction database.


Nurit Gal , Daniela Digles , Cizar , Lauren J. Dupuis , Friederike Ehrhart , and Eric Weitz


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Mus musculus



Pathway Ontology

transforming growth factor-beta superfamily mediated signaling pathway


Label Type Compact URI Comment
Tgfbr3 GeneProduct ncbigene:21814
Zeb2 GeneProduct ncbigene:24136
Tgfb1 GeneProduct ncbigene:21803
Smad9 GeneProduct ncbigene:55994
Jak1 GeneProduct ncbigene:16451
Mapk9 GeneProduct ncbigene:26420
Smad1 GeneProduct ncbigene:17125
Runx2 GeneProduct ncbigene:12393
Tgif1 GeneProduct ncbigene:21815
Ski GeneProduct ncbigene:20481
Smad4 GeneProduct ncbigene:17128
Bmp4 GeneProduct ncbigene:12159
Tnf GeneProduct ncbigene:21926
Fst GeneProduct ncbigene:14313
Fkbp1a GeneProduct ncbigene:14225
Spp1 GeneProduct ncbigene:20750
Wnt1 GeneProduct ncbigene:22408
Tgfbr2 GeneProduct ncbigene:21813
Thbs1 GeneProduct ncbigene:21825 there are 5 types of tsp
Lif GeneProduct ncbigene:16878
Nog GeneProduct ncbigene:18121
Lef1 GeneProduct ncbigene:16842
Eng GeneProduct ncbigene:13805
Smad6 GeneProduct ncbigene:17130
Bmp4 GeneProduct ncbigene:12159
Skil GeneProduct ncbigene:20482
Zfp423 GeneProduct ncbigene:94187
Mapk3 GeneProduct ncbigene:26417
Runx3 GeneProduct ncbigene:12399
Tgfbr1 GeneProduct ncbigene:21812
Nfkb1 GeneProduct ncbigene:18033
Smad3 GeneProduct ncbigene:17127
Bambi GeneProduct ncbigene:68010
Ep300 GeneProduct ncbigene:328572
Serpine1 GeneProduct ncbigene:18787
Smad1 GeneProduct ncbigene:17125
Inhba GeneProduct ncbigene:16323
Ltbp1 GeneProduct ncbigene:268977
Smad2 GeneProduct ncbigene:17126
Stat3 GeneProduct ncbigene:20848
Tgfbr2 GeneProduct ncbigene:21813
Zfyve9 GeneProduct ncbigene:230597
Ifng GeneProduct ncbigene:15978
Tgfb1 GeneProduct ncbigene:21803
Jun GeneProduct ncbigene:16476
Smad2 GeneProduct ncbigene:17126
Smad7 GeneProduct ncbigene:17131
Foxh1 GeneProduct ncbigene:14106
Hras1 GeneProduct ncbigene:15461
Ctnnb1 GeneProduct ncbigene:12387
Tnf GeneProduct ncbigene:21926
Fos GeneProduct ncbigene:14281
Tcfe3 GeneProduct ncbigene:209446
Egf GeneProduct ncbigene:13645
Stat1 GeneProduct ncbigene:20846
Crebbp GeneProduct ncbigene:12914
Tgfbr1 GeneProduct ncbigene:21812
Smad5 GeneProduct ncbigene:17129
Itgb6 GeneProduct ncbigene:16420


  1. TGFbeta signaling in growth control, cancer, and heritable disorders. Massagué J, Blain SW, Lo RS. Cell. 2000 Oct 13;103(2):295–309. PubMed Europe PMC Scholia
  2. How cells read TGF-beta signals. Massagué J. Nat Rev Mol Cell Biol. 2000 Dec;1(3):169–78. PubMed Europe PMC Scholia