Eicosanoid synthesis (WP1090)

Canis familiaris

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]


Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz


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Canis familiaris



Pathway Ontology

eicosanoid biosynthetic pathway


Label Type Compact URI Comment
5-HPETE Metabolite hmdb:HMDB0001193
Prostaglandin H2 Metabolite hmdb:HMDB0001381
Leukotriene D4 Metabolite hmdb:HMDB0003080
Thromboxane B2 Metabolite hmdb:HMDB0003252
Prostaglandin I2 Metabolite hmdb:HMDB0001335
Prostaglandin D2 Metabolite hmdb:HMDB0001403
Leukotriene A4 Metabolite hmdb:HMDB0001337
Prostaglandin F2a Metabolite hmdb:HMDB0001139
Leukotriene C4 Metabolite hmdb:HMDB0001198
Leukotriene E4 Metabolite hmdb:HMDB0002200
Thromboxane A2 Metabolite hmdb:HMDB0001452
Arachidonic acid Metabolite hmdb:HMDB0001043
Leukotriene B4 Metabolite hmdb:HMDB0001085
ALOX5AP GeneProduct ncbigene:477323
PTGDS GeneProduct ncbigene:403740
PTGES2 GeneProduct ncbigene:609101
DPEP1 GeneProduct ncbigene:479611
PTGIS GeneProduct ncbigene:485919
ALOX5 GeneProduct ncbigene:477753
TBXAS1 GeneProduct ncbigene:482771
PTGS1 GeneProduct ncbigene:403544
GGT1 GeneProduct ncbigene:486400
PLA2G6 GeneProduct ncbigene:481256
ALOX15 GeneProduct ncbigene:489458
ALOX15B GeneProduct ncbigene:489485
PTGES GeneProduct ncbigene:480698
PLA2G6 GeneProduct ncbigene:481256
ALOX5 GeneProduct ncbigene:477753
LTA4H GeneProduct ncbigene:482611
PTGS2 GeneProduct ncbigene:442942
LTC4S GeneProduct ncbigene:607316
ALOX15 GeneProduct ncbigene:489458
ALOX5AP GeneProduct ncbigene:477323
PNPLA8 GeneProduct ncbigene:475880
ALOX12 GeneProduct ncbigene:479476


  1. Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia