Sulfur amino acid biosynthesis (WP7)

Saccharomyces cerevisiae

The synthesis of methionine and cysteine (among other sulfur-containing compounds) from sulfate, ATP, NADPH, and serine.


Jessica Heckman , Kristina Hanspers , Egon Willighagen , Daniela Digles , Denise Slenter , Alex Pico , and Eric Weitz


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Saccharomyces cerevisiae



Pathway Ontology

cysteine and methionine metabolic pathway


Label Type Compact URI Comment
Coenzyme A Metabolite cas:64885-97-8
ATP Metabolite cas:1927-31-7
homoserine Metabolite cas:672-15-1
L-serine Metabolite cas:56-45-1
L-methionine Metabolite cas:63-68-3
NADPH Metabolite cas:53-57-6
3 NADPH Metabolite cas:53-57-6
acetate Metabolite cas:64-19-7
acetyl-CoA Metabolite cas:72-89-9
adenosine-3',5'-bisphosphate Metabolite cas:3805-37-6
phosphate Metabolite cas:14265-44-2
pyrophosphate Metabolite cas:2466-09-3
L-cysteine Metabolite cas:52-90-4
ADP Metabolite cas:58-64-0
cystathionine Metabolite cas:535-34-2
homocysteine Metabolite cas:6027-13-0
STR2 GeneProduct sgd:S000003891
STR3 GeneProduct sgd:S000003152
CYS4 GeneProduct sgd:S000003387
MET16 GeneProduct sgd:S000006371
MET10 GeneProduct sgd:S000001926
MET6 GeneProduct sgd:S000000893 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
ECM17 GeneProduct sgd:S000003898
MET3 GeneProduct sgd:S000003771
SAM1 GeneProduct sgd:S000004170
MET14 GeneProduct sgd:S000001484
MET17 GeneProduct sgd:S000004294
MET2 GeneProduct sgd:S000005221
SAM2 GeneProduct sgd:S000002910
CYS3 GeneProduct sgd:S000000010


  1. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Thomas D, Surdin-Kerjan Y. Microbiol Mol Biol Rev. 1997 Dec;61(4):503–32. PubMed Europe PMC Scholia