Poly(glycerol phosphate) wall teichoic acid biosynthesis (WP4162)
Saccharomyces cerevisiae
Teichoic acids serve several roles in the cell. They serve as reservoirs of phosphates that can be mobilized when phosphate becomes limiting. Being anionic, they are scavengers of cations (in particular Mg2+), and may create a pH gradient across the wall by sequestering the protons expelled through the cytoplasmic membrane. In addition, lipoteichoic acids are the main source of the hydrophobicity of the cell envelope, and may contribute to its adhesiveness. Teichoic acids are also immunogenic, and can be considered the Gram-positive equivalent of the Gram-negative lipopolysaccharides.
Authors
Denise Slenter , Egon Willighagen , Andra Waagmeester , Eric Weitz , Alex Pico , and Lars WillighagenActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited By
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Label | Type | Compact Identifier | Comment |
---|---|---|---|
2 H+ | Metabolite | chebi:15378 | |
D-alanine | Metabolite | wikidata:Q27076975 | |
ATP | Metabolite | pubchem.compound:5461108 | |
ManNAc-GlcNAc-PP-undecaprenol | Metabolite | pubchem.compound:121225527 | |
diphosphate | Metabolite | wikidata:Q290828 | |
UDP-alpha-D-glucose (n) | Metabolite | wikidata:Q27126319 | |
H+ | Metabolite | chebi:15378 | |
H+ | Metabolite | chebi:15378 | |
2-O-D-alanyl-1-O-phosphatidylglycerol | Metabolite | wikidata:Q46328873 | |
di-trans,octa-cis-undecaprenyl diphosphate | Metabolite | wikidata:Q27125764 | |
UDP-N-acetyl-alpha-D-mannosamine | Metabolite | wikidata:Q27137103 | |
an L-1-phosphatidyl-sn-glycerol | Metabolite | wikidata:Q46326783 | |
ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-beta-D-glucosaminyl)-(1,4-)]-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine | Metabolite | wikidata:Q46330436 | |
UDP | Metabolite | chebi:17659 | |
a peptidoglycan-major wall teichoic acid complex | Metabolite | wikidata:Q46330851 | |
H2O | Metabolite | wikidata:Q283 | |
CDP-glycerol | Metabolite | wikidata:Q27102700 | |
ATP | Metabolite | wikidata:Q80863 | |
phosphate | Metabolite | wikidata:Q177811 | |
AMP | Metabolite | pubchem.compound:15938965 | |
N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol | Metabolite | pubchem.compound:52921677 | |
H2O | Metabolite | wikidata:Q283 | |
CDP-glycerol | Metabolite | pubchem.compound:90659090 | |
CMP (n) | Metabolite | chebi:60377 | |
diphosphate | Metabolite | wikidata:Q290828 | |
sn-glycerol-3-phosphate | Metabolite | pubchem.compound:7048686 | |
a polyisoprenyl-major wall techoic acid | Metabolite | wikidata:Q46329416 | |
di-trans,octa-cis-undecaprenyl phosphate | Metabolite | wikidata:Q27127244 | |
UDP | Metabolite | wikidata:Q412593 | |
UDP-N-acety-alpha-D-glucosamide | Metabolite | wikidata:Q312208 | |
Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | pubchem.compound:122706646 | |
di-trans,octa-cis-undecaprenyl phosphate | Metabolite | wikidata:Q27127302 | |
UMP | Metabolite | wikidata:Q27074278 | |
H+ | Metabolite | chebi:15378 | |
CMP | Metabolite | chebi:60377 | |
H+ | Metabolite | chebi:15378 | |
CTP | Metabolite | wikidata:Q409648 | cytidine triphosphate |
(Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | chebi:132224 | |
((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | chebi:132356 | |
((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | chebi:132356 | |
ADP | Metabolite | wikidata:Q185253 | |
H+ | Metabolite | chebi:15378 | |
an L-1-phosphatidyl-sn-glycerol | Metabolite | wikidata:Q46326783 | |
Bs-tagA | Protein | eccode:2.4.1.187 | UDP-N-acetylmannosamine transferase (Bs) |
Bs-tagB | Protein | eccode:2.7.8.44 | Teichoic acid glycerol-phosphate primase (Bs) |
a D-alanyl-carrier protein | Protein | wikidata:Q24771273 | |
Bs-mnaA | Protein | eccode:5.1.3.14 | UDP-N-acetylglucosamine 2-epimerase (BS) |
Bs-dltA | Protein | eccode:6.2.1.M5 | D-alanine-[D-alanyl carrier protein] ligase (Bs) |
Bs-tagO | Protein | eccode:2.7.8.33 | UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (Bs) |
Bs-tagD | Protein | eccode:2.7.7.39 | glycerol-3-phosphate-cytidyltransferase (Bs) |
Bs-tagF | Protein | eccode:2.7.8.12 | Teichoic acid poly(glycerol-phosphate) polymerase (Bs) |
Bs-tagE | Protein | eccode:2.4.1.52 | Poly(glycerol-phosphate)alpha-glucosyltranferase (Bs) |
Bs-tagH + Bs-tagG | Protein | eccode:3.6.3.40 | Poly(glycerol-phosphate) teichoic acid transporter (Bs) |
Bs-dltD | Protein | eccode:2.3.1.M31 | D-alanine carrier protein:PG D-alanyltransferase (Bs) |
Bs-dltB | Protein | eccode:2.3.1.M32 | PG: teichoic acid D-alanyltransferase (Bs) |
Bs-tagV + Bs-tagU + Bs-tagT | Protein | eccode:2.7.8.M1 | Polyisoprenyl-major teichoic acid -- peptidoglycan teichoic acis transferase |
References
- Gale RT, Sewell EW, Garrett TA, Brown ED. Reconstituting poly(glycerol phosphate) wall teichoic acid biosynthesis in vitro using authentic substrates. Chem Sci [Internet]. 2014 Jun 17;5(10):3823. Available from: http://dx.doi.org/10.1039/C4SC00802B DOI