Poly(glycerol phosphate) wall teichoic acid biosynthesis (WP4162)
Saccharomyces cerevisiae
Teichoic acids serve several roles in the cell. They serve as reservoirs of phosphates that can be mobilized when phosphate becomes limiting. Being anionic, they are scavengers of cations (in particular Mg²⁺), and may create a pH gradient across the wall by sequestering the protons expelled through the cytoplasmic membrane. In addition, lipoteichoic acids are the main source of the hydrophobicity of the cell envelope, and may contribute to its adhesiveness. Teichoic acids are also immunogenic, and can be considered the Gram-positive equivalent of the Gram-negative lipopolysaccharides.
Authors
Denise Slenter , Egon Willighagen , Andra Waagmeester , Eric Weitz , Alex Pico , and Lars WillighagenActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
classic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 2 H+ | Metabolite | chebi:15378 | |
| D-alanine | Metabolite | wikidata:Q27076975 | |
| ATP | Metabolite | pubchem.compound:5461108 | |
| ManNAc-GlcNAc-PP-undecaprenol | Metabolite | pubchem.compound:121225527 | |
| diphosphate | Metabolite | wikidata:Q290828 | |
| UDP-alpha-D-glucose (n) | Metabolite | wikidata:Q27126319 | |
| H+ | Metabolite | chebi:15378 | |
| H+ | Metabolite | chebi:15378 | |
| 2-O-D-alanyl-1-O-phosphatidylglycerol | Metabolite | wikidata:Q46328873 | |
| di-trans,octa-cis-undecaprenyl diphosphate | Metabolite | wikidata:Q27125764 | |
| UDP-N-acetyl-alpha-D-mannosamine | Metabolite | wikidata:Q27137103 | |
| an L-1-phosphatidyl-sn-glycerol | Metabolite | wikidata:Q46326783 | |
| ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-beta-D-glucosaminyl)-(1,4-)]-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine | Metabolite | wikidata:Q46330436 | |
| UDP | Metabolite | chebi:17659 | |
| a peptidoglycan-major wall teichoic acid complex | Metabolite | wikidata:Q46330851 | |
| H2O | Metabolite | wikidata:Q283 | |
| CDP-glycerol | Metabolite | wikidata:Q27102700 | |
| ATP | Metabolite | wikidata:Q80863 | |
| phosphate | Metabolite | wikidata:Q177811 | |
| AMP | Metabolite | pubchem.compound:15938965 | |
| N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol | Metabolite | pubchem.compound:52921677 | |
| H2O | Metabolite | wikidata:Q283 | |
| CDP-glycerol | Metabolite | pubchem.compound:90659090 | |
| CMP (n) | Metabolite | chebi:60377 | |
| diphosphate | Metabolite | wikidata:Q290828 | |
| sn-glycerol-3-phosphate | Metabolite | pubchem.compound:7048686 | |
| a polyisoprenyl-major wall techoic acid | Metabolite | wikidata:Q46329416 | |
| di-trans,octa-cis-undecaprenyl phosphate | Metabolite | wikidata:Q27127244 | |
| UDP | Metabolite | wikidata:Q412593 | |
| UDP-N-acety-alpha-D-glucosamide | Metabolite | wikidata:Q312208 | |
| Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | pubchem.compound:122706646 | |
| di-trans,octa-cis-undecaprenyl phosphate | Metabolite | wikidata:Q27127302 | |
| UMP | Metabolite | wikidata:Q27074278 | |
| H+ | Metabolite | chebi:15378 | |
| CMP | Metabolite | chebi:60377 | |
| H+ | Metabolite | chebi:15378 | |
| CTP | Metabolite | wikidata:Q409648 | cytidine triphosphate |
| (Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | chebi:132224 | |
| ((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | chebi:132356 | |
| ((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol | Metabolite | chebi:132356 | |
| ADP | Metabolite | wikidata:Q185253 | |
| H+ | Metabolite | chebi:15378 | |
| an L-1-phosphatidyl-sn-glycerol | Metabolite | wikidata:Q46326783 | |
| Bs-tagA | Protein | eccode:2.4.1.187 | UDP-N-acetylmannosamine transferase (Bs) |
| Bs-tagB | Protein | eccode:2.7.8.44 | Teichoic acid glycerol-phosphate primase (Bs) |
| a D-alanyl-carrier protein | Protein | wikidata:Q24771273 | |
| Bs-mnaA | Protein | eccode:5.1.3.14 | UDP-N-acetylglucosamine 2-epimerase (BS) |
| Bs-dltA | Protein | eccode:6.2.1.M5 | D-alanine-[D-alanyl carrier protein] ligase (Bs) |
| Bs-tagO | Protein | eccode:2.7.8.33 | UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (Bs) |
| Bs-tagD | Protein | eccode:2.7.7.39 | glycerol-3-phosphate-cytidyltransferase (Bs) |
| Bs-tagF | Protein | eccode:2.7.8.12 | Teichoic acid poly(glycerol-phosphate) polymerase (Bs) |
| Bs-tagE | Protein | eccode:2.4.1.52 | Poly(glycerol-phosphate)alpha-glucosyltranferase (Bs) |
| Bs-tagH + Bs-tagG | Protein | eccode:3.6.3.40 | Poly(glycerol-phosphate) teichoic acid transporter (Bs) |
| Bs-dltD | Protein | eccode:2.3.1.M31 | D-alanine carrier protein:PG D-alanyltransferase (Bs) |
| Bs-dltB | Protein | eccode:2.3.1.M32 | PG: teichoic acid D-alanyltransferase (Bs) |
| Bs-tagV + Bs-tagU + Bs-tagT | Protein | eccode:2.7.8.M1 | Polyisoprenyl-major teichoic acid -- peptidoglycan teichoic acis transferase |