Poly(glycerol phosphate) wall teichoic acid biosynthesis (WP4162)

Saccharomyces cerevisiae

Teichoic acids serve several roles in the cell. They serve as reservoirs of phosphates that can be mobilized when phosphate becomes limiting. Being anionic, they are scavengers of cations (in particular Mg²⁺), and may create a pH gradient across the wall by sequestering the protons expelled through the cytoplasmic membrane. In addition, lipoteichoic acids are the main source of the hydrophobicity of the cell envelope, and may contribute to its adhesiveness. Teichoic acids are also immunogenic, and can be considered the Gram-positive equivalent of the Gram-negative lipopolysaccharides.


Denise Slenter , Egon Willighagen , Andra Waagmeester , Eric Weitz , Alex Pico , and Lars Willighagen


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Saccharomyces cerevisiae



Pathway Ontology

classic metabolic pathway


Label Type Compact URI Comment
2 H+ Metabolite chebi:15378
D-alanine Metabolite wikidata:Q27076975
ATP Metabolite pubchem.compound:5461108
ManNAc-GlcNAc-PP-undecaprenol Metabolite pubchem.compound:121225527
diphosphate Metabolite wikidata:Q290828
UDP-alpha-D-glucose (n) Metabolite wikidata:Q27126319
H+ Metabolite chebi:15378
H+ Metabolite chebi:15378
2-O-D-alanyl-1-O-phosphatidylglycerol Metabolite wikidata:Q46328873
di-trans,octa-cis-undecaprenyl diphosphate Metabolite wikidata:Q27125764
UDP-N-acetyl-alpha-D-mannosamine Metabolite wikidata:Q27137103
an L-1-phosphatidyl-sn-glycerol Metabolite wikidata:Q46326783
ditrans,octacis-undecaprenyldiphospho-[(N-acetyl-beta-D-glucosaminyl)-(1,4-)]-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine Metabolite wikidata:Q46330436
UDP Metabolite chebi:17659
a peptidoglycan-major wall teichoic acid complex Metabolite wikidata:Q46330851
H2O Metabolite wikidata:Q283
CDP-glycerol Metabolite wikidata:Q27102700
ATP Metabolite wikidata:Q80863
phosphate Metabolite wikidata:Q177811
AMP Metabolite pubchem.compound:15938965
N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol Metabolite pubchem.compound:52921677
H2O Metabolite wikidata:Q283
CDP-glycerol Metabolite pubchem.compound:90659090
CMP (n) Metabolite chebi:60377
diphosphate Metabolite wikidata:Q290828
sn-glycerol-3-phosphate Metabolite pubchem.compound:7048686
a polyisoprenyl-major wall techoic acid Metabolite wikidata:Q46329416
di-trans,octa-cis-undecaprenyl phosphate Metabolite wikidata:Q27127244
UDP Metabolite wikidata:Q412593
UDP-N-acety-alpha-D-glucosamide Metabolite wikidata:Q312208
Gro-P-ManNac-GlcNAc-PP-undecaprenol Metabolite pubchem.compound:122706646
di-trans,octa-cis-undecaprenyl phosphate Metabolite wikidata:Q27127302
UMP Metabolite wikidata:Q27074278
H+ Metabolite chebi:15378
CMP Metabolite chebi:60377
H+ Metabolite chebi:15378
CTP Metabolite wikidata:Q409648 cytidine triphosphate
(Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol Metabolite chebi:132224
((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol Metabolite chebi:132356
((2-Glc)Gro-P)n Gro-P-ManNac-GlcNAc-PP-undecaprenol Metabolite chebi:132356
ADP Metabolite wikidata:Q185253
H+ Metabolite chebi:15378
an L-1-phosphatidyl-sn-glycerol Metabolite wikidata:Q46326783
Bs-tagA Protein eccode: UDP-N-acetylmannosamine transferase (Bs)
Bs-tagB Protein eccode: Teichoic acid glycerol-phosphate primase (Bs)
a D-alanyl-carrier protein Protein wikidata:Q24771273
Bs-mnaA Protein eccode: UDP-N-acetylglucosamine 2-epimerase (BS)
Bs-dltA Protein eccode:6.2.1.M5 D-alanine-[D-alanyl carrier protein] ligase (Bs)
Bs-tagO Protein eccode: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (Bs)
Bs-tagD Protein eccode: glycerol-3-phosphate-cytidyltransferase (Bs)
Bs-tagF Protein eccode: Teichoic acid poly(glycerol-phosphate) polymerase (Bs)
Bs-tagE Protein eccode: Poly(glycerol-phosphate)alpha-glucosyltranferase (Bs)
Bs-tagH + Bs-tagG Protein eccode: Poly(glycerol-phosphate) teichoic acid transporter (Bs)
Bs-dltD Protein eccode:2.3.1.M31 D-alanine carrier protein:PG D-alanyltransferase (Bs)
Bs-dltB Protein eccode:2.3.1.M32 PG: teichoic acid D-alanyltransferase (Bs)
Bs-tagV + Bs-tagU + Bs-tagT Protein eccode:2.7.8.M1 Polyisoprenyl-major teichoic acid -- peptidoglycan teichoic acis transferase


  1. Reconstituting poly(glycerol phosphate) wall teichoic acid biosynthesis in vitro using authentic substrates. Gale RT, Sewell EW, Garrett TA, Brown ED. Chem Sci [Internet]. 2014 Jun 17;5(10):3823. Available from: http://dx.doi.org/10.1039/C4SC00802B DOI Scholia