TPO and NIS inhibition leading to neurodevelopmental abnormalities (WP5227)
Adverse Outcome Pathway for the effect of thyroid hormone disruption
AuthorsCeline Malyar , Marvin Martens , and Eric Weitz
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CommunitiesAdverse Outcome Pathways
Pathway Ontologythyroid hormone signaling pathway
- Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments? Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, et al. Crit Rev Toxicol. 2020 Oct;50(9):740–63. PubMed Europe PMC Scholia
- Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments? Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, et al. Crit Rev Toxicol. 2021 Apr;51(4):328–58. PubMed Europe PMC Scholia