FAS pathway and stress induction of HSP regulation (WP511)

Danio rerio

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This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Thomas Kelder , Kristina Hanspers , Christine Chichester , Lauren J. Dupuis , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

stress response pathway FasL mediated signaling pathway

Participants

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Ceramide Metabolite cas:104404-17-3
spna2 GeneProduct ncbigene:553383 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
faf1 GeneProduct ncbigene:406243
casp7 GeneProduct ncbigene:553634
hspb1 GeneProduct ncbigene:368243
ripk2 GeneProduct ncbigene:373874 receptor (TNFRSF)-interacting serine-threonine kinase 2
dffb GeneProduct ncbigene:373130
pak1 GeneProduct ncbigene:373103
apaf1 GeneProduct ncbigene:58131
daxx GeneProduct ncbigene:561006
mapkapk2a GeneProduct ncbigene:327321
casp8 GeneProduct ncbigene:58022
parp1 GeneProduct ncbigene:560788
dffa GeneProduct ncbigene:436904
arhgdig GeneProduct ncbigene:394132 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
cycsb GeneProduct ncbigene:415158
faslg GeneProduct ncbigene:735295
fadd GeneProduct ncbigene:562317
casp8l2 GeneProduct ncbigene:557302
rb1 GeneProduct ncbigene:777733
mapk8a GeneProduct ncbigene:562720
jun GeneProduct ncbigene:335916
mapkapk3 GeneProduct ncbigene:790934
map2k4a GeneProduct ncbigene:403052
casp6 GeneProduct ncbigene:552927
pak2a GeneProduct ncbigene:266749
map3k7 GeneProduct ncbigene:553788
lmnb1 GeneProduct ncbigene:195816
lmnb2 GeneProduct ncbigene:30196
casp9 GeneProduct ncbigene:492763
cflar GeneProduct ncbigene:373114
LOC100334486 GeneProduct ncbigene:100334486
wu:fa96e12 GeneProduct ncbigene:562283
lmna GeneProduct ncbigene:195815
fas GeneProduct ncbigene:768248

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia