TCA cycle (aka Krebs or citric acid cycle) (WP78)

Homo sapiens

The [[wikipedia:citric_acid_cycle|citric acid cycle]], also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both [[wikipedia:Albert_Szent-Gyorgyi|Albert Szent-Gyorgyi]] and [[wikipedia:Hans_Krebs|Hans Krebs]]. Source: Wikipedia ([[wikipedia:citric_acid_cycle]]) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP78 CPTAC Assay Portal].

Authors

Kdahlquist , Martijn Van Iersel , Alex Pico , Thomas Kelder , Nick Fidelman , Kristina Hanspers , Ray Andrews II , Harm Nijveen , Miranda Stobbe , Sander Houten , Daniela Digles , Egon Willighagen , Denise Slenter , Finterly Hu , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway citric acid cycle pathway citric acid cycle pathway

Participants

Label Type Compact URI Comment
GTP Metabolite hmdb:HMDB0001273 The ChEBI ID with the correct charge is: 37565
GDP Metabolite hmdb:HMDB0001201 The ChEBI ID with the correct charge is: 58189
CO2 Metabolite hmdb:HMDB0001967
water Metabolite hmdb:HMDB0002111
NADH Metabolite hmdb:HMDB0001487 The ChEBI ID with the correct charge is: 57945
oxaloacetate Metabolite hmdb:HMDB0000223
ubiquinone-10 Metabolite hmdb:HMDB0001072
cis-aconitate Metabolite hmdb:HMDB0000072 The ChEBI ID with the correct charge is: 16383
NADP Metabolite hmdb:HMDB0000217
D-threo-Isocitrate Metabolite hmdb:HMDB0000193 The ChEBI ID with the correct charge is: 15562
NAD Metabolite hmdb:HMDB0000902
ubiquinol-10 Metabolite hmdb:HMDB0013111
(S)-malate Metabolite hmdb:HMDB0000156
succinate Metabolite hmdb:HMDB0000254 The ChEBI ID with the correct charge is: 30031
ATP Metabolite hmdb:HMDB0000538 The ChEBI ID with the correct charge is: 30616
CoA Metabolite hmdb:HMDB0001423 The ChEBI ID with the correct charge is: 57287
acetyl-CoA Metabolite hmdb:HMDB0001206 The ChEBI ID with the correct charge is: 57288
2-oxoglutarate Metabolite hmdb:HMDB0000208
ADP Metabolite hmdb:HMDB0001341 The ChEBI ID with the correct charge is: 456216
NADPH Metabolite hmdb:HMDB0000221 The ChEBI ID with the correct charge is: 57783
citrate Metabolite hmdb:HMDB0000094
CoA Metabolite hmdb:HMDB0001423 The ChEBI ID with the correct charge is: 57287
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fumarate Metabolite hmdb:HMDB0000134
succinyl-CoA Metabolite hmdb:HMDB0001022 The ChEBI ID with the correct charge is: 57292
Pi Metabolite hmdb:HMDB0001429
IDH3B GeneProduct ncbigene:3420
SDHA GeneProduct ncbigene:6389
SUCLG2 GeneProduct ncbigene:8801
ACO2 GeneProduct ncbigene:50
SUCLG1 GeneProduct ncbigene:8802
DLST GeneProduct ncbigene:1743
IDH3G GeneProduct ncbigene:3421
SDHC GeneProduct ncbigene:6391
IDH2 GeneProduct ncbigene:3418
SDHD GeneProduct ncbigene:6392
SDHB GeneProduct ncbigene:6390
CS GeneProduct ncbigene:1431
IDH3A GeneProduct ncbigene:3419
DLD GeneProduct ncbigene:1738
OGDH GeneProduct ncbigene:4967
FH GeneProduct ncbigene:2271
MDH2 GeneProduct ncbigene:4191
SUCLA2 GeneProduct uniprot:Q9P2R7

References

  1. Urinary organic acids in man. I. Normal patterns. Lawson AM, Chalmers RA, Watts RW. Clin Chem. 1976 Aug;22(8):1283–7. PubMed Europe PMC Scholia
  2. Physiological roles of nicotinamide nucleotide transhydrogenase. Hoek JB, Rydström J. Biochem J. 1988 Aug 15;254(1):1–10. PubMed Europe PMC Scholia
  3. Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria. Gabriel JL, Zervos PR, Plaut GW. Metabolism. 1986 Jul;35(7):661–7. PubMed Europe PMC Scholia
  4. The role of citric acid in intermediate metabolism in animal tissues. Krebs HA, Johnson WA. FEBS Lett. 1980 Aug 25;117 Suppl:K1-10. PubMed Europe PMC Scholia
  5. Citrate synthesis in intact rat-liver mitochondria is irreversible. Greksák M, Lopes-Cardozo M, van den Bergh SG. Eur J Biochem. 1982 Feb;122(2):423–7. PubMed Europe PMC Scholia
  6. Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, et al. J Biol Chem. 1995 Apr 28;270(17):10027–36. PubMed Europe PMC Scholia
  7. Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates. Fernandez CA, Des Rosiers C. J Biol Chem. 1995 Apr 28;270(17):10037–42. PubMed Europe PMC Scholia
  8. Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates. Des Rosiers C, Fernandez CA, David F, Brunengraber H. J Biol Chem. 1994 Nov 4;269(44):27179–82. PubMed Europe PMC Scholia
  9. Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria. Sazanov LA, Jackson JB. FEBS Lett. 1994 May 16;344(2–3):109–16. PubMed Europe PMC Scholia
  10. Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient. Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5186–90. PubMed Europe PMC Scholia
  11. Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit. Johnson JD, Muhonen WW, Lambeth DO. J Biol Chem. 1998 Oct 16;273(42):27573–9. PubMed Europe PMC Scholia
  12. The alpha-ketoglutarate dehydrogenase complex. Sheu KF, Blass JP. Ann N Y Acad Sci. 1999;893:61–78. PubMed Europe PMC Scholia
  13. Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia. Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1505-14. PubMed Europe PMC Scholia
  14. The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase. KREBS HA, HOLZACH O. Biochem J. 1952 Nov;52(3):527–8. PubMed Europe PMC Scholia
  15. Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues. Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI. J Biol Chem. 2004 Aug 27;279(35):36621–4. PubMed Europe PMC Scholia