TCA cycle (aka Krebs or citric acid cycle) (WP78)

Homo sapiens

Authors

Kdahlquist , Martijn Van Iersel , Alex Pico , Thomas Kelder , Nick Fidelman , Kristina Hanspers , Ray Andrews II , Harm Nijveen , Miranda Stobbe , Sander Houten , Daniela Digles , Egon Willighagen , Denise Slenter , Finterly Hu , and Eric Weitz

Activity

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Cited In

• Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning (2022).
• DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
• ConsensusPathDB 2022: molecular interactions update as a resource for network biology (2022).
• Ten simple rules for creating reusable pathway models for computational analysis and visualization (2021).
• Exploring the cellular network of metabolic flexibility in the adipose tissue (2018).
• Pathway analysis of transcriptomic data shows immunometabolic effects of vitamin D (2018).
• Transcriptional reprogramming of metabolic pathways in critically ill patients (2016).

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway citric acid cycle pathway citric acid cycle pathway

References

1. Urinary organic acids in man. I. Normal patterns. Lawson AM, Chalmers RA, Watts RW. Clin Chem. 1976 Aug;22(8):1283–7. PubMed Europe PMC Scholia
2. Physiological roles of nicotinamide nucleotide transhydrogenase. Hoek JB, Rydström J. Biochem J. 1988 Aug 15;254(1):1–10. PubMed Europe PMC Scholia
3. Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria. Gabriel JL, Zervos PR, Plaut GW. Metabolism. 1986 Jul;35(7):661–7. PubMed Europe PMC Scholia
4. The role of citric acid in intermediate metabolism in animal tissues. Krebs HA, Johnson WA. FEBS Lett. 1980 Aug 25;117 Suppl:K1-10. PubMed Europe PMC Scholia
5. Citrate synthesis in intact rat-liver mitochondria is irreversible. Greksák M, Lopes-Cardozo M, van den Bergh SG. Eur J Biochem. 1982 Feb;122(2):423–7. PubMed Europe PMC Scholia
6. Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, et al. J Biol Chem. 1995 Apr 28;270(17):10027–36. PubMed Europe PMC Scholia
7. Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates. Fernandez CA, Des Rosiers C. J Biol Chem. 1995 Apr 28;270(17):10037–42. PubMed Europe PMC Scholia
8. Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates. Des Rosiers C, Fernandez CA, David F, Brunengraber H. J Biol Chem. 1994 Nov 4;269(44):27179–82. PubMed Europe PMC Scholia
9. Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria. Sazanov LA, Jackson JB. FEBS Lett. 1994 May 16;344(2–3):109–16. PubMed Europe PMC Scholia
10. Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient. Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5186–90. PubMed Europe PMC Scholia
11. Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit. Johnson JD, Muhonen WW, Lambeth DO. J Biol Chem. 1998 Oct 16;273(42):27573–9. PubMed Europe PMC Scholia
12. The alpha-ketoglutarate dehydrogenase complex. Sheu KF, Blass JP. Ann N Y Acad Sci. 1999;893:61–78. PubMed Europe PMC Scholia
13. Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia. Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1505-14. PubMed Europe PMC Scholia
14. The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase. KREBS HA, HOLZACH O. Biochem J. 1952 Nov;52(3):527–8. PubMed Europe PMC Scholia
15. Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues. Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI. J Biol Chem. 2004 Aug 27;279(35):36621–4. PubMed Europe PMC Scholia