Adipogenesis (WP236)

Homo sapiens

The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from preadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Mary-Elizabeth Patti , Kristina Hanspers , Nathan Salomonis , Martijn Van Iersel , Alex Pico , and Andika Tan


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Homo sapiens



Pathway Ontology

signaling pathway pertinent to development

Cell Type Ontology



Label Type Compact URI Comment
IGF1 GeneProduct ncbigene:3479
PTGIS GeneProduct ncbigene:5740
PPARD GeneProduct ncbigene:5467
CREB1 GeneProduct ncbigene:1385
MIXL1 GeneProduct ncbigene:83881
GH1 GeneProduct ncbigene:2688
ID3 GeneProduct ncbigene:3399
WNT10B GeneProduct ncbigene:7480
STAT5A GeneProduct ncbigene:6776
STAT5B GeneProduct ncbigene:6777
DLK1 GeneProduct ncbigene:8788
NR3C1 GeneProduct ncbigene:2908
DDIT3 GeneProduct ncbigene:1649
LIF GeneProduct ncbigene:3976
CEBPB GeneProduct ncbigene:1051
CYP26A1 GeneProduct ncbigene:1592
CYP26B1 GeneProduct ncbigene:56603
RXRA GeneProduct ncbigene:6256
RARA GeneProduct ncbigene:5914
NR1H3 GeneProduct ncbigene:10062
LPL GeneProduct ncbigene:4023
SREBF1 GeneProduct ncbigene:6720
FAS GeneProduct ncbigene:355
RBL1 GeneProduct ncbigene:5933
GATA3 GeneProduct ncbigene:2625
GATA2 GeneProduct ncbigene:2624
PPARG GeneProduct ncbigene:5468
MEF2A GeneProduct ncbigene:4205
MEF2B GeneProduct ncbigene:4207
MEF2C GeneProduct ncbigene:4208
MEF2D GeneProduct ncbigene:4209
ASIP GeneProduct ncbigene:434
TNF GeneProduct ncbigene:7124
MIF GeneProduct ncbigene:4282
TGFB1 GeneProduct ncbigene:7040
SERPINE1 GeneProduct ncbigene:5054
SLC2A4 GeneProduct ncbigene:6517
SCD GeneProduct ncbigene:6319
TWIST1 GeneProduct ncbigene:7291
LEP GeneProduct ncbigene:3952
RETN GeneProduct ncbigene:56729
DF GeneProduct ncbigene:1675
GTF3A GeneProduct ncbigene:2971
RB1 GeneProduct ncbigene:5925
RBL2 GeneProduct ncbigene:5934
ADIPOQ GeneProduct ncbigene:9370
ADFP GeneProduct ncbigene:123
AGT GeneProduct ncbigene:183
CDKN1A GeneProduct ncbigene:1026
E2F1 GeneProduct ncbigene:1869
SP1 GeneProduct ncbigene:6667
HMGA1 GeneProduct ncbigene:3159
PLIN GeneProduct ncbigene:5346
IL6 GeneProduct ncbigene:3569
GADD45A GeneProduct ncbigene:1647
GADD45B GeneProduct ncbigene:4616
CEBPD GeneProduct ncbigene:1052
BMP1 GeneProduct ncbigene:649
BMP2 GeneProduct ncbigene:650
BMP3 GeneProduct ncbigene:651
BMP4 GeneProduct ncbigene:652
NDN GeneProduct ncbigene:4692
FOXO1A GeneProduct ncbigene:2308
KLF5 GeneProduct ncbigene:688
FOXC2 GeneProduct ncbigene:2303
PPARGC1A GeneProduct ncbigene:10891
NCOA1 GeneProduct ncbigene:8648
NCOA2 GeneProduct ncbigene:10499
PPARA GeneProduct ncbigene:5465
STAT3 GeneProduct ncbigene:6774
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
STAT6 GeneProduct ncbigene:6778
SOCS1 GeneProduct ncbigene:8651
SOCS3 GeneProduct ncbigene:9021
CNTFR GeneProduct ncbigene:1271
LIFR GeneProduct ncbigene:3977
IL6ST GeneProduct ncbigene:3572
MBNL1 GeneProduct ncbigene:4154
OSM GeneProduct ncbigene:5008
CTNNB1 GeneProduct ncbigene:1499
UCP1 GeneProduct ncbigene:7350
WNT5B GeneProduct ncbigene:81029
WNT1 GeneProduct ncbigene:7471
SMAD3 GeneProduct ncbigene:4088
FZD1 GeneProduct ncbigene:8321
DVL1 GeneProduct ncbigene:1855
TCF1 GeneProduct ncbigene:6927
RXRG GeneProduct ncbigene:6258
FRZB GeneProduct ncbigene:2487
INS GeneProduct ncbigene:3630
PBEF1 GeneProduct ncbigene:10135
SPOCK GeneProduct ncbigene:6695
TRIB3 GeneProduct ncbigene:57761
GATA4 GeneProduct ncbigene:2626
NR2F1 GeneProduct ncbigene:7025
NRIP1 GeneProduct ncbigene:8204
RORA GeneProduct ncbigene:6095
PRLR GeneProduct ncbigene:5618
ADPN GeneProduct ncbigene:80339
CUGBP1 GeneProduct ncbigene:10658
HIF1A GeneProduct ncbigene:3091
KLF6 GeneProduct ncbigene:1316
KLF7 GeneProduct ncbigene:8609
SFRP4 GeneProduct ncbigene:6424
NCOR1 GeneProduct ncbigene:9611
NCOR2 GeneProduct ncbigene:9612
KLF15 GeneProduct ncbigene:28999
EGR2 GeneProduct ncbigene:1959
EBF GeneProduct ncbigene:1879
EPAS1 GeneProduct ncbigene:2034
AHR GeneProduct ncbigene:196
C10orf70 GeneProduct ncbigene:55847
WWTR1 GeneProduct ncbigene:25937
GDF10 GeneProduct ncbigene:2662
IRS1 GeneProduct ncbigene:3667
IRS4 GeneProduct ncbigene:8471
BSCL2 GeneProduct ncbigene:26580
LMNA GeneProduct ncbigene:4000
AGPAT2 GeneProduct ncbigene:10555
ZMPSTE24 GeneProduct ncbigene:10269
LPIN1 GeneProduct ncbigene:23175
LPIN2 GeneProduct ncbigene:9663
LIPE GeneProduct ncbigene:3991
PCK1 GeneProduct ncbigene:5105
PCK2 GeneProduct ncbigene:5106
CEBPA GeneProduct ncbigene:1050
IRS2 GeneProduct ncbigene:8660
IRS3P GeneProduct ncbigene:442338
LPIN3 GeneProduct ncbigene:64900
E2F4 GeneProduct ncbigene:1874


  1. Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia