Sildenafil treatment (WP5294)

Homo sapiens

Sildenafil treatment


Cenna Doornbos , Egon Willighagen , and Denise Slenter


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Homo sapiens



Disease Ontology

impotence hypertension pulmonary hypertension

Pathway Ontology

mitochondrial disease pathway


Label Type Compact URI Comment
cGMP Metabolite chebi:16356
Nitric oxide Metabolite chebi:16480
AMP Metabolite chebi:16027
GTP Metabolite chebi:37565
GAPDH inhibitors Metabolite chebi:70817
GMP Metabolite chebi:17345
tideglusib Metabolite chebi:147398
sildenafil Metabolite chebi:9139
PDE4inhibitors Metabolite chebi:68844
AKT1 GeneProduct ensembl:ENSG00000142208
TFAM GeneProduct ensembl:ENSG00000108064
PRKG1 GeneProduct ensembl:ENSG00000185532
PRKN GeneProduct ensembl:ENSG00000185345
AKT2 GeneProduct ensembl:ENSG00000105221
ZNF746 GeneProduct ensembl:ENSG00000181220
NRF1 GeneProduct ensembl:ENSG00000106459
GUCY1A2 GeneProduct ensembl:ENSG00000152402
GAPDH GeneProduct ensembl:ENSG00000111640
PDE5 GeneProduct ensembl:ENSG00000138735 Inhibition of cGMP degradation by PDE5 increases cGMP availability [PMID:9714779].
PDE4A GeneProduct ensembl:ENSG00000065989
PDE4D GeneProduct ensembl:ENSG00000113448
GSK3B GeneProduct ensembl:ENSG00000082701
PPARGC1A GeneProduct ensembl:ENSG00000109819 Alternative name is PGC1A [uniprot:Q9UBK2]
PDE4C GeneProduct ensembl:ENSG00000105650
NOS1 GeneProduct ensembl:ENSG00000089250
PDE4B GeneProduct ensembl:ENSG00000184588
GUCY1B2 GeneProduct ensembl:ENSG00000123201
GUCY1A1 GeneProduct ensembl:ENSG00000164116 Also known as GUCY1A3 [uniprot:Q02108].
GUCY1B1 GeneProduct ensembl:ENSG00000061918 Also known as GUCY1B3 [uniprot:Q02153].
AKT3 GeneProduct ensembl:ENSG00000117020
NOS3 GeneProduct ensembl:ENSG00000164867 NOS3 is implicated in vascular smooth muscle relaxation through cGMP [PMID:1378832,PMID:20590592].
NOS2 GeneProduct ensembl:ENSG00000007171


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