Glial cell differentiation (WP2276)

Homo sapiens

Glial cells, consisting of microglia, astrocytes, and oligodendrocyte lineage cells as their major components, constitute a large fraction of the mammalian brain. Originally considered as purely non-functional glue for neurons, decades of research have highlighted the importance as well as further functions of glial cells. Source: Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Nathan Salomonis , Alex Pico , Ryan Miller , Denise Slenter , Egon Willighagen , Kristina Hanspers , and Eric Weitz


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Homo sapiens



Cell Type Ontology

neural cell neuronal stem cell stem cell glial cell oligodendrocyte precursor cell

Pathway Ontology

signaling pathway signaling pathway pertinent to development


Label Type Compact URI Comment
PLP1 GeneProduct ensembl:ENSG00000123560
CNP GeneProduct ensembl:ENSG00000173786
TPPP GeneProduct ensembl:ENSG00000171368
miR-206 GeneProduct ensembl:ENSG00000207604
GAP43 GeneProduct ensembl:ENSG00000172020
MSN GeneProduct ensembl:ENSG00000147065
MBP GeneProduct ensembl:ENSG00000197971
MAG GeneProduct ensembl:ENSG00000105695


  1. Down-regulation of GAP-43 During Oligodendrocyte Development and Lack of Expression by Astrocytes In Vivo: Implications for Macroglial Differentiation. Curtis R, Hardy R, Reynolds R, Spruce BA, Wilkin GP. Eur J Neurosci. 1991;3(9):876–86. PubMed Europe PMC Scholia
  2. Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, Lau P, Tokési N, Muja N, Hudson LD, Ovádi J. Glia. 2010 Jan 15;58(2):157–68. PubMed Europe PMC Scholia
  3. Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation. Cai J, Tuong CM, Zhang Y, Shields CB, Guo G, Fu H, et al. J Pathol. 2012 Feb;226(3):495–508. PubMed Europe PMC Scholia