Nuclear receptors (WP217)

Rattus norvegicus

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia ([[wikipedia:Nuclear_receptor]])


Ellen Tuninsky , Manny Ramirez , Alex Pico , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


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Rattus norvegicus



Pathway Ontology

transcription factor mediated signaling pathway


Label Type Compact URI Comment
Thra GeneProduct ncbigene:81812
Thrb GeneProduct ncbigene:24831
Thrb GeneProduct ncbigene:24831
Rara GeneProduct ncbigene:24705
RARB GeneProduct ncbigene:24706
Rarg GeneProduct ncbigene:685072
Rarg GeneProduct ncbigene:685072
Ppara GeneProduct ncbigene:25747
Ppard GeneProduct ncbigene:25682
Pparg GeneProduct ncbigene:25664
Pparg GeneProduct ncbigene:25664
NR1D2 GeneProduct ncbigene:259241
Nr0b1 GeneProduct ncbigene:58850
Ror1 GeneProduct ncbigene:362550
Rora GeneProduct ncbigene:300807
Rorc GeneProduct ncbigene:368158
Nr1h2 GeneProduct ncbigene:58851
Nr1h3 GeneProduct ncbigene:58852
Vdr GeneProduct ncbigene:24873
Hnf4a GeneProduct ncbigene:25735
Rxra GeneProduct ncbigene:25271
Rxrb GeneProduct ncbigene:361801
Rxrg GeneProduct ncbigene:83574
Nr2c2 GeneProduct ncbigene:50659
Nr2f1 GeneProduct ncbigene:81808
Nr2f2 GeneProduct ncbigene:113984
Nr2f6 GeneProduct ncbigene:245980
NR2E1 GeneProduct ncbigene:684085
Esr1 GeneProduct ncbigene:24890
Esr2 GeneProduct ncbigene:25149
Esrra GeneProduct ncbigene:293701
Esrrb GeneProduct ncbigene:299210
Nr3c1 GeneProduct ncbigene:24413
Pgr GeneProduct ncbigene:25154
Ar GeneProduct ncbigene:24208
Nr4a1 GeneProduct ncbigene:79240
Nr4a2 GeneProduct ncbigene:54278
Nr5a1 GeneProduct ncbigene:83826
Nr5a2 GeneProduct ncbigene:60349
Nr1i2 GeneProduct ncbigene:84385
Nr1i3 GeneProduct ncbigene:65035


  1. Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease. Nagy L, Schüle R, Gronemeyer H. EMBO Rep. 2006 Jun;7(6):579–84. PubMed Europe PMC Scholia