Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex (WP4884)

Homo sapiens

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis


Rex D A B , Kristina Hanspers , Egon Willighagen , Alex Pico , Eric Weitz , Finterly Hu , and Isabel Wassink


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Homo sapiens




Pathway Ontology

disease pathway regulatory pathway inflammatory response pathway

Disease Ontology

viral infectious disease COVID-19 severe acute respiratory syndrome


Label Type Compact URI Comment
IGLC2 GeneProduct ncbigene:3538
IGHE GeneProduct ncbigene:3497
HLA-DRA GeneProduct ncbigene:3122
CD4 GeneProduct ncbigene:920
CD8B GeneProduct ncbigene:926
HLA-DRB1 GeneProduct ncbigene:3123
IGLL1 GeneProduct ncbigene:3543
PRG3 GeneProduct ncbigene:10394
CD8A GeneProduct ncbigene:925
CRP GeneProduct ncbigene:1401
MMP25 GeneProduct ncbigene:64386
LBP GeneProduct ncbigene:3929
HLA-DRB4 GeneProduct ncbigene:3126
IGHG4 GeneProduct ncbigene:3503
IL-8 GeneProduct ncbigene:3576
IGHG2 GeneProduct ncbigene:3501
NKRF GeneProduct ncbigene:55922
CD2 GeneProduct ncbigene:914
NLRP1 GeneProduct ncbigene:5725029
HLA-DRB5 GeneProduct ncbigene:3127
IGHG1 GeneProduct ncbigene:3500
IL-6 GeneProduct ncbigene:3569
CD247 GeneProduct ncbigene:919
CD3G GeneProduct ncbigene:917
LCK GeneProduct ncbigene:3932
CD3E GeneProduct ncbigene:916
ZAP70 GeneProduct ncbigene:7535
TRBC1 GeneProduct ncbigene:28639
FYN GeneProduct ncbigene:2534
TRAC GeneProduct ncbigene:28755
nsp9 Protein wikidata:Q89686805
nsp10 Protein wikidata:Q87917572


  1. Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. Li J, Guo M, Tian X, Wang X, Yang X, Wu P, et al. Med (N Y). 2021 Jan 15;2(1):99-112.e7. PubMed Europe PMC Scholia