ERK1-ERK2 MAPK cascade (WP402)

Danio rerio

The MAPK signaling proteins are involved in many eukaryotic cellular processes and signaling networks. The upstream activation pathways for ERK1 and ERK2 are highly similar, and also many of their known downstream targets are common; however these genes exhibit different knockdown phenotypes and there are diverse roles for these kinases during embryogenesis. For ERK1 specific genes are involved in dorsal-ventral patterning and subsequent embryonic cell migration. For ERK2, several genes are involved in cell-migration, mesendoderm differentiation and patterning.


Gabby Krens , Kristina Hanspers , Thomas Kelder , Christine Chichester , Marvin Martens , Andra Waagmeester , Denise Slenter , Friederike Ehrhart , Egon Willighagen , and Eric Weitz


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Danio rerio



Pathway Ontology

the extracellular signal-regulated Raf/Mek/Erk signaling pathway


Label Type Compact URI Comment
tgfb2 GeneProduct ncbigene:369194
fos GeneProduct ncbigene:394198
atf7b GeneProduct ncbigene:568197
atf1 GeneProduct ncbigene:325609
fgf17b GeneProduct ncbigene:407737
mapk8b GeneProduct ensembl:ENSDARG00000009870
cmycb GeneProduct ncbigene:393141
igf2 GeneProduct ncbigene:30710
mapkapk5 GeneProduct ncbigene:436608
map3k5 / ask1# GeneProduct ncbigene:555703
sos2* GeneProduct ensembl:ENSDARG00000060506
mapk6 / ERK3# GeneProduct ncbigene:565830
tgfb3 GeneProduct ncbigene:369195
Rap1a GeneProduct ncbigene:415242
aRAF# GeneProduct ncbigene:30716
mkp3 / dusp6 GeneProduct ncbigene:353314
fgf21* GeneProduct uniprot:Q1ESX2
sh3glb1 GeneProduct ncbigene:334911
grb2 GeneProduct ncbigene:406308
fgfr4 GeneProduct ncbigene:30706
mych GeneProduct ncbigene:338151
fgf5 GeneProduct ncbigene:494454
pdgfrb2# GeneProduct ncbigene:360210
sh3glb2 GeneProduct ncbigene:402885
spry4 GeneProduct ncbigene:114437
hgfa GeneProduct ensembl:ENSDARG00000045544
ntl GeneProduct ncbigene:30399
fgf14 GeneProduct ncbigene:497642
mapk7 /ERK5# GeneProduct ncbigene:541323
nr2f5 GeneProduct ensembl:ENSDARG00000033172
mapkapk2 GeneProduct ncbigene:327321
mycl1b GeneProduct ncbigene:327350
pea GeneProduct ncbigene:30700
cryab GeneProduct ncbigene:30393
spry2 GeneProduct ncbigene:335098
atf4 GeneProduct ncbigene:406514
vegfc GeneProduct ensembl:ENSDARG00000069640
mkp2 / dusp4 GeneProduct ncbigene:394146
cPLA2 GeneProduct ncbigene:30554
mapk1 / ERK2 GeneProduct ncbigene:360144
MAP3K8 / TPL-2 / Cot# GeneProduct ncbigene:563727
fgf10b GeneProduct ensembl:ENSDARG00000100475
mapk4 / ERK4 GeneProduct ncbigene:406782
fgfrl1b GeneProduct ncbigene:497135
tgfbr2 GeneProduct ensembl:ENSDARG00000034541
srf GeneProduct ncbigene:30431
pdgfrb1# GeneProduct ncbigene:378846
her1 GeneProduct ncbigene:30287
rps6ka1 / RSK1* GeneProduct zfin:ZDB-GENE-060929-516
fgf17a GeneProduct ncbigene:65089
cmyca GeneProduct ncbigene:30686
max GeneProduct ncbigene:30467
ER alpha GeneProduct ncbigene:259252
th GeneProduct ncbigene:30384
egf GeneProduct ensembl:ENSDARG00000052739
usf2 GeneProduct ncbigene:406475
sh3gl3 GeneProduct ncbigene:393150
mycn GeneProduct ncbigene:252851
atf3 GeneProduct ncbigene:393939
shc GeneProduct ncbigene:333933
sos1 GeneProduct ensembl:ENSDARG00000042468
jun GeneProduct ncbigene:335916
mkp1 / dusp1 GeneProduct ncbigene:406340
tgfb1 GeneProduct ncbigene:359834
fgf2 GeneProduct ensembl:ENSDARG00000104348
fgf1 GeneProduct ncbigene:393733
pdgfa GeneProduct ncbigene:378480
fgf8 GeneProduct ncbigene:30538
MBP GeneProduct ncbigene:326281
PTP1b GeneProduct ncbigene:30081
mknk2 / MNK2 GeneProduct ncbigene:373121
atf2l GeneProduct ncbigene:378449
rras2 GeneProduct ensembl:ENSDARG00000036252
AP-1 GeneProduct ncbigene:335916
fgf12# GeneProduct ncbigene:497641
fgf4 GeneProduct ncbigene:60311
elk4 / sap1 GeneProduct ncbigene:30093
raf1b GeneProduct ensembl:ENSDARG00000059406
fgf7 GeneProduct ncbigene:493181
il17rd GeneProduct ensembl:ENSDARG00000098359
map2k4a GeneProduct ensembl:ENSDARG00000063583
mapk14b / p38b GeneProduct ncbigene:266756
pdgfra GeneProduct ncbigene:30745
elk3 GeneProduct ncbigene:557074
fgf13 GeneProduct ncbigene:492758
fgfr2 GeneProduct ncbigene:352940
mapk3 / ERK1 GeneProduct ncbigene:399480
map3k7 / tak1 GeneProduct ncbigene:553788
rps6kal / RSK1 GeneProduct ncbigene:337670
hRas GeneProduct ncbigene:550286
ERM GeneProduct ncbigene:30452
hgf2# GeneProduct ncbigene:493782
fgf19# GeneProduct ncbigene:368245
fgf20b# GeneProduct ncbigene:564770
mapk14a / p38a GeneProduct ncbigene:65237
sh3gl2 GeneProduct ncbigene:394091
igf GeneProduct ncbigene:114433
creb1 GeneProduct ncbigene:393883
kdr GeneProduct ensembl:ENSDARG00000017321
fgf20a# GeneProduct ncbigene:559630
eif4e1a GeneProduct ncbigene:79380
vegfaa GeneProduct ensembl:ENSDARG00000103542
cebpb GeneProduct ncbigene:140814
ngf1b# GeneProduct ncbigene:30469
eEf2K GeneProduct ncbigene:266639
kRASa GeneProduct ncbigene:393228
junbl GeneProduct ncbigene:336038
aRAFl GeneProduct ncbigene:403063
fgf18l# GeneProduct ncbigene:497639
sh3glb2 GeneProduct ncbigene:394094
atf7a GeneProduct ncbigene:566279
fgfrl1a GeneProduct ncbigene:393347
mos GeneProduct ncbigene:402817
bad GeneProduct ncbigene:58100
map4k2 GeneProduct ensembl:ENSDARG00000001234
ngfr# GeneProduct ncbigene:323817
fgf10 GeneProduct ncbigene:359830
fgf24 GeneProduct ncbigene:359831
hsf1 GeneProduct ncbigene:58123
igf1rb GeneProduct ensembl:ENSDARG00000034434
fgfr1op2 GeneProduct ncbigene:335511
mapk2k2 GeneProduct ncbigene:336209
rps6ka3 / RSK2 GeneProduct ncbigene:338219
fgf16 GeneProduct ncbigene:692065
map2k1 / MEK1 GeneProduct ncbigene:406728
mapk15 / ERK7 GeneProduct ncbigene:553780
igf1ra GeneProduct ncbigene:245701
fgfr1 GeneProduct ncbigene:30705
MEKK 4# GeneProduct ncbigene:30495
map2k6 GeneProduct ensembl:ENSDARG00000099184
eif4e1b GeneProduct ncbigene:30738
map2k2 / MEK2 GeneProduct ncbigene:563181
igf2r# GeneProduct ncbigene:557061
fgf6 GeneProduct ncbigene:30560
fgfr3 GeneProduct ncbigene:58129
mycl1a GeneProduct ncbigene:405873
egfra GeneProduct ensembl:ENSDARG00000013847
fgf11# GeneProduct ncbigene:497640
ngfra# GeneProduct ncbigene:368715
map3k4 / Mekk4# GeneProduct ncbigene:30495
junb GeneProduct ncbigene:407086
fgf13l GeneProduct ncbigene:403003
fgf23 GeneProduct ncbigene:494456
map4k5 GeneProduct ncbigene:334565
PAC1 / dusp2 GeneProduct ncbigene:445057
fgf22 GeneProduct ensembl:ENSDARG00000076510
nRAS GeneProduct ncbigene:30380
braf GeneProduct ensembl:ENSDARG00000017661
fgf3 GeneProduct ncbigene:30549
fgf18a GeneProduct ensembl:ENSDARG00000088048
sh3glb2 GeneProduct ncbigene:664773


  1. Characterization and expression patterns of the MAPK family in zebrafish. Krens SFG, He S, Spaink HP, Snaar-Jagalska BE. Gene Expr Patterns. 2006 Oct;6(8):1019–26. PubMed Europe PMC Scholia
  2. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SFG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. BMC Genomics. 2008 Apr 28;9:196. PubMed Europe PMC Scholia