Kit receptor signaling pathway (WP147)

Rattus norvegicus

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath


Akhilesh Pandey , Alex Pico , Daniela Digles , and Eric Weitz


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Rattus norvegicus



Pathway Ontology

Stem Cell Factor signaling pathway


Label Type Compact URI Comment
Grb7 GeneProduct ncbigene:84427
Pik3r1 GeneProduct ncbigene:25513
Pik3r2 GeneProduct ncbigene:29741
Shc1 GeneProduct ncbigene:85385
Csf2rb GeneProduct ncbigene:171081
Grb2 GeneProduct ncbigene:81504
Socs6 GeneProduct ncbigene:307200
Socs4 GeneProduct ncbigene:305828
Socs5 GeneProduct ncbigene:500616
Cish GeneProduct ncbigene:83681
Cltc GeneProduct ncbigene:54241
Crk GeneProduct ncbigene:54245
Src GeneProduct ncbigene:83805
Plce1 GeneProduct ncbigene:114633
Jak2 GeneProduct ncbigene:24514
Grap GeneProduct ncbigene:363616
Ptpru GeneProduct ncbigene:116680
Stap1 GeneProduct ncbigene:305269
Prkca GeneProduct ncbigene:24680
Plcg1 GeneProduct ncbigene:25738
Stat1 GeneProduct ncbigene:25124
Stat5a GeneProduct ncbigene:24918
Stat5b GeneProduct ncbigene:25126
Pik3cg GeneProduct ncbigene:298947
Sh2b2 GeneProduct ncbigene:114203
Grb10 GeneProduct ncbigene:498416
Akt1 GeneProduct ncbigene:24185
Tec GeneProduct ncbigene:84492
Lyn GeneProduct ncbigene:81515
Dok1 GeneProduct ncbigene:312477
Ptpn6 GeneProduct ncbigene:116689
Ptpn11 GeneProduct ncbigene:25622
Epor GeneProduct ncbigene:24336
Rps6ka1 GeneProduct ncbigene:81771
Mitf GeneProduct ncbigene:25094
Mapk1 GeneProduct ncbigene:116590
Abl1 GeneProduct ncbigene:311860
Inpp5d GeneProduct ncbigene:54259
Fgr GeneProduct ncbigene:79113
Hck GeneProduct ncbigene:25734
Yes1 GeneProduct ncbigene:24884
Rasa1 GeneProduct ncbigene:25676
Fes GeneProduct ncbigene:361597
Crkl GeneProduct ncbigene:287942
Cbl GeneProduct ncbigene:500985
Socs1 GeneProduct ncbigene:252971
Vav1 GeneProduct ncbigene:25156
Vav2 GeneProduct ncbigene:296603
Matk GeneProduct ncbigene:60450
Bad GeneProduct ncbigene:64639
Sos1 GeneProduct ncbigene:313845
Ep300 GeneProduct ncbigene:170915
Fyn GeneProduct ncbigene:25150
Prkcb GeneProduct ncbigene:25023
Hras GeneProduct ncbigene:293621
Raf1 GeneProduct ncbigene:24703
Spred2 GeneProduct ncbigene:305539
Spred1 GeneProduct ncbigene:296072
Sh3kbp1 GeneProduct ncbigene:84357
Cblb GeneProduct ncbigene:171136
Tnfrsf10b GeneProduct ncbigene:364420
Btk GeneProduct ncbigene:367901
Kit GeneProduct ncbigene:64030
Kitlg GeneProduct ncbigene:60427
Kit GeneProduct ncbigene:64030
Kitlg GeneProduct ncbigene:60427
Map2k1 GeneProduct ncbigene:170851
Stat3 GeneProduct ncbigene:25125
Mpdz GeneProduct ncbigene:29365
Dok1 GeneProduct ncbigene:312477