Sulindac metabolic pathway (WP2541)

Rattus norvegicus

Metabolism of sulindac involves various enzymes.


Egon Willighagen , Marianthi Kalafati , Denise Slenter , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Rattus norvegicus



Pathway Ontology

classic metabolic pathway xenobiotic metabolic pathway


Label Type Compact URI Comment
Sulindac sulfide Metabolite chemspider:4509492
Sulindac-S Metabolite pubchem.compound:11245227
Sulindac-R Metabolite pubchem.compound:16046677
Sulindac sulfone Metabolite chemspider:4582441 The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
CYP1A1 GeneProduct ensembl:ENSRNOG00000019500
MsrB2 GeneProduct ensembl:ENSRNOG00000016873
MsrA GeneProduct ensembl:ENSRNOG00000012440
FMO GeneProduct interpro:IPR000960
MsrB3 GeneProduct ensembl:ENSRNOG00000042668
CYP1A2 GeneProduct ensembl:ENSRNOG00000016173


  1. Studies on the metabolism and biological activity of the epimers of sulindac. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H. Drug Metab Dispos. 2011 Jun;39(6):1014–21. PubMed Europe PMC Scholia