Lysine biosynthesis (WP533)

Saccharomyces cerevisiae

S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipic acid pathway instead of the diaminopmelate pathway (CITS: [10714900]). Originally proposed to be characteristic of fungi, recent studies suggest prokaryotes also synthesize lysine via the alpha-aminoadipic acid pathway (CITS: [11029074]). Intermediates in this pathway are often incorporated into secondary metabolites. For example, it has been well- studied that alpha-aminoadipate is required for penicillin production (CITS: [10714900]). Regulation of the lysine biosynthetic pathway in S. cerevisiae is an interaction between general amino acid control (via Gcn4p) (CITS: [Hinnebusch]), feedback inhibition of homocitrate synthase activity by lysine (CITS: [10103047]), and induction of Lys14p by alpha-aminoadipate semialdehyde (CITS: [10975256]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Authors

Meredith Braymer , Daniela Digles , Egon Willighagen , Eric Weitz , and Kristina Hanspers

Activity

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

lysine biosynthetic pathway classic metabolic pathway

Participants

Label Type Compact URI Comment
L-glutamate Metabolite cas:56-86-0
L-Saccharopine Metabolite chebi:16927
2-oxoglutarate Metabolite chebi:16810
L-lysine Metabolite cas:56-87-1
cis-homoaconitate Metabolite hmdb:HMDB60320
NADH Metabolite cas:53-84-9
NADH Metabolite cas:53-84-9
diphosphate Metabolite hmdb:HMDB00250
Coenzyme A Metabolite cas:64885-97-8
(1R,2S)-homoisocitrate Metabolite chebi:15404
H2O Metabolite hmdb:HMDB02111
L-glutamate Metabolite cas:56-86-0
Homocitrate Metabolite chebi:36457
CO2 Metabolite chebi:16526
2-oxoadipate Metabolite hmdb:HMDB00225
L-2-aminoadipate Metabolite hmdb:HMDB00510
NADPH Metabolite cas:53-57-6
(S)-2-amino-6-oxohexanoate Metabolite hmdb:HMDB59595
acetyl-CoA Metabolite cas:72-89-9
2-oxoglutarate Metabolite chebi:16810
NADP+ Metabolite hmdb:HMDB00217
H+ Metabolite hmdb:HMDB59597
NAD+ Metabolite hmdb:HMDB00902
ATP Metabolite hmdb:HMDB00538
AMP Metabolite hmdb:HMDB00045
H2O Metabolite hmdb:HMDB02111
H2O Metabolite hmdb:HMDB02111
H2O Metabolite hmdb:HMDB02111
H2O Metabolite hmdb:HMDB02111
H+ Metabolite hmdb:HMDB59597
2-oxoglutarate Metabolite chebi:16810
NAD+ Metabolite hmdb:HMDB00902
H+ Metabolite hmdb:HMDB59597
NADPH Metabolite cas:53-57-6
H+ Metabolite hmdb:HMDB59597
NADP+ Metabolite hmdb:HMDB00217
LYS12 GeneProduct sgd:S000001356
LYS2 GeneProduct sgd:S000000319
LYS1 GeneProduct sgd:S000001473
LYS21 GeneProduct sgd:S000002289
LYS4 GeneProduct sgd:S000002642
ARO8 GeneProduct ensembl:YGL202W
LYS20 GeneProduct sgd:S000002341
LYS9 GeneProduct sgd:S000005333

References

  1. Lysine biosynthesis and metabolism in fungi. Zabriskie TM, Jackson MD. Nat Prod Rep. 2000 Feb;17(1):85–97. PubMed Europe PMC Scholia