Fatty acid biosynthesis (WP357)

Homo sapiens

The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP357 CPTAC Assay Portal]


Kdahlquist , Michiel Adriaens , Alex Pico , Chris Evelo , JT. Saito , Jildau Bouwman , Martijn Van Iersel , Egon Willighagen , Martina Summer-Kutmon , Friederike Ehrhart , Kristina Hanspers , Denise Slenter , Eric Weitz , and Luiz C. M. Ladeira


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Homo sapiens



Pathway Ontology

fatty acid biosynthetic pathway


Label Type Compact URI Comment
3-L-Hydroxyacyl-CoA Metabolite chebi:57318
Acetyl-ACP Metabolite wikidata:Q59811305
Crotonoyl-ACP Metabolite kegg.compound:C04618 aka (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
Oxaloacetate Metabolite chebi:30744
Fatty acyl CoA Metabolite chebi:37554
Palmitate Metabolite chemspider:440215
Malonyl-ACP Metabolite kegg.compound:C01209
Butyryl-ACP Metabolite chebi:3247
Acetoacetyl-ACP Metabolite chebi:2393
Palmitoyl-ACP Metabolite kegg.compound:C16520
Citrate Metabolite chemspider:29081
pyruvate Metabolite chebi:15361
Long-Chain fatty acid Metabolite chebi:15904
3-ketoacyl-CoA Metabolite chebi:57347 aka 3-oxo-fatty acyl-CoA(4−)
Malonyl-CoA Metabolite cas:524-14-1 Used in small tissue samples as [14C] isotope tracer to improve sensiticity of FASN activity. [https://doi.org/10.1515/bchm3.1986.367.2.905]
Acetyl-CoA Metabolite chebi:15351
Acyl-CoA (n+2) Metabolite chebi:17984
FASN GeneProduct ncbigene:2194
ECHS1 GeneProduct ncbigene:1892
ACSL5 GeneProduct ncbigene:51703
FASN GeneProduct ncbigene:2194
PECR GeneProduct ncbigene:55825
ECHDC2 GeneProduct ncbigene:55268
ACACA GeneProduct ncbigene:31
ECHDC1 GeneProduct ncbigene:55862
ACSL4 GeneProduct ncbigene:2182
FASN GeneProduct ncbigene:2194
SCD GeneProduct ncbigene:6319
ACAS2 GeneProduct ncbigene:55902
FASN GeneProduct ncbigene:2194
ECHDC3 GeneProduct ncbigene:79746
FASN GeneProduct ncbigene:2194
ACLY GeneProduct ncbigene:47
FASN GeneProduct ncbigene:2194
ACSL3 GeneProduct ncbigene:2181
HADHSC GeneProduct ncbigene:3033
FASN GeneProduct ncbigene:2194
ACACB GeneProduct ncbigene:32
ACSL1 GeneProduct ncbigene:2180
PC GeneProduct ncbigene:5091
ACAA2 GeneProduct ncbigene:10449
FASN GeneProduct ncbigene:2194
MECR GeneProduct ncbigene:51102
DECR1 GeneProduct ncbigene:1666
ACSL6 GeneProduct ncbigene:23305
ECH1 GeneProduct ncbigene:1891
Acetyl-synthase Protein ensembl:ENSG00000131069


  1. Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E, et al. Biol Chem Hoppe Seyler. 1986 Sep;367(9):905–12. PubMed Europe PMC Scholia