Glycine metabolism (WP1495)

Homo sapiens

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Glycine is degraded through three pathways: The glycine cleavage system (GCS); by serine hydroxymethyltransferase, and conversion to glyoxylate. In animals, the main pathway is GCS, which is essentially the reverse of the glycine synthase pathway. Degradation of by serine hydroxymethyltransferase happens in two steps. First, glycine is converted to serine by serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase. Glycine can also be converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate. Description adapted from Wikipedia.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Essam Sharaf , Kristina Hanspers , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

ONTOX

Annotations

Pathway Ontology

glycine metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
H₂O₂ Metabolite chebi:16240
Serine Metabolite chebi:17115
H₂O Metabolite chebi:15377
O₂ Metabolite chebi:15379
Pyruvate Metabolite chemspider:96901
Glutamate Metabolite chemspider:4302384
MTHF Metabolite chemspider:97272
Bile Salts Metabolite chebi:36277
Glycine Metabolite hmdb:HMDB0000123
Creatine Metabolite pubchem.compound:586
Heme Metabolite chebi:30413
Purines Metabolite chebi:26401
a-Iminoacetate Metabolite chebi:53664
Glyoxalate Metabolite pubchem.compound:760
Oxalate Metabolite pubchem.compound:971
Glutathione Metabolite pubchem.compound:124886
SHMT1 GeneProduct ncbigene:6470
SHMT2 GeneProduct ncbigene:6472
Glycine Oxidase GeneProduct eccode:1.4.3.19
Glycine Transaminase GeneProduct eccode:2.6.1.4
MTHFR GeneProduct ensembl:ENSG00000177000

References

  1. Glycine. Hall JC. JPEN J Parenter Enteral Nutr. 1998;22(6):393–8. PubMed Europe PMC Scholia
  2. Glycine metabolism in animals and humans: implications for nutrition and health. Wang W, Wu Z, Dai Z, Yang Y, Wang J, Wu G. Amino Acids. 2013 Sep;45(3):463–77. PubMed Europe PMC Scholia