Glycine metabolism (WP1495)

Homo sapiens

Glycine is degraded via three pathways. The predominant pathway in animals and plants is the reverse of the glycine synthase pathway. In this context, the enzyme system involved is usually called the glycine cleavage system. In the second pathway, glycine is degraded in two steps. The first step is the reverse of glycine biosynthesis from serine with serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase. In the third pathway of glycine degradation, glycine is converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction. Description source: [ Wikipedia]


Essam Sharaf , Kristina Hanspers , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz


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Homo sapiens



Pathway Ontology

glycine metabolic pathway


Label Type Compact URI Comment
Serine Metabolite chemspider:597
Pyruvate Metabolite chemspider:96901
Glutamate Metabolite chemspider:4302384
MTHF Metabolite chemspider:97272
Bile Salts Metabolite chebi:36277
Glycine Metabolite hmdb:HMDB0000123
Creatine Metabolite pubchem.compound:586
Heme Metabolite chebi:30413
Purines Metabolite chebi:26401
a-Iminoacetate Metabolite chebi:53664
Glyoxalate Metabolite pubchem.compound:760
Oxalate Metabolite pubchem.compound:971
Glutathione Metabolite pubchem.compound:124886
SHMT1 GeneProduct ncbigene:6470
SHMT2 GeneProduct ncbigene:6472
Glycine Oxidase GeneProduct eccode:
Glycine Transaminase GeneProduct eccode:
MTHFR GeneProduct ensembl:ENSG00000177000