Spinal cord injury (WP2432)

Mus musculus

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.


Nathan Salomonis , Egon Willighagen , Deborah Micael , Chris Evelo , Linda Rieswijk , and Eric Weitz


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Mus musculus



Disease Ontology

spinal cord disease post-traumatic stress disorder

Pathway Ontology

disease pathway

Cell Type Ontology

astrocyte of the spinal cord


Label Type Compact URI Comment
LTB4 Metabolite pubchem.compound:169
NO Metabolite pubchem.compound:145068
melittin Metabolite pubchem.compound:16133648
FK506 Metabolite cas:104987-11-3
FK506 Metabolite cas:104987-11-3
FK506 Metabolite cas:104987-11-3
FK506 Metabolite cas:104987-11-3
Arachidonic acid Metabolite hmdb:HMDB0001043
PGH2 Metabolite hmdb:HMDB0001381
Olomoucine Metabolite hmdb:HMDB0035233
Ngfr GeneProduct ensembl:ENSMUSG00000000120
Tnfsf13 GeneProduct ensembl:ENSMUSG00000089669
Ltb4r1 GeneProduct ensembl:ENSMUSG00000046908
Tnfsf13b GeneProduct ensembl:ENSMUSG00000031497
Ptprz1 GeneProduct ensembl:ENSMUSG00000068748
Pdyn GeneProduct ensembl:ENSMUSG00000027400
Ltb GeneProduct ensembl:ENSMUSG00000024399
Plxna2 GeneProduct ensembl:ENSMUSG00000026640
Cspg4 GeneProduct ensembl:ENSMUSG00000032911
Cd47 GeneProduct ensembl:ENSMUSG00000055447
Zfp36 GeneProduct ensembl:ENSMUSG00000044786
Fcgr2b GeneProduct ensembl:ENSMUSG00000026656
Prb1 GeneProduct ensembl:ENSMUSG00000067543
Ptpra GeneProduct ensembl:ENSMUSG00000027303
Il1b GeneProduct ensembl:ENSMUSG00000027398
Zfp36 GeneProduct ensembl:ENSMUSG00000044786
Nos2 GeneProduct ensembl:ENSMUSG00000020826
Tnf GeneProduct ensembl:ENSMUSG00000024401
Nr4a1 GeneProduct ensembl:ENSMUSG00000023034
Il4 GeneProduct ensembl:ENSMUSG00000000869
Btg2 GeneProduct ensembl:ENSMUSG00000020423
Btg2 GeneProduct ensembl:ENSMUSG00000020423
Cdk2 GeneProduct ensembl:ENSMUSG00000025358
Nos1 GeneProduct ensembl:ENSMUSG00000029361
Il2 GeneProduct ensembl:ENSMUSG00000027720
Tnf GeneProduct ensembl:ENSMUSG00000024401
Il6 GeneProduct ensembl:ENSMUSG00000025746
Tlr4 GeneProduct ensembl:ENSMUSG00000039005
Fos GeneProduct ensembl:ENSMUSG00000021250
Il1b GeneProduct ensembl:ENSMUSG00000027398
Tgfb1 GeneProduct ensembl:ENSMUSG00000002603
Tlr4 GeneProduct ensembl:ENSMUSG00000039005
Tnf GeneProduct ensembl:ENSMUSG00000024401
Egr1 GeneProduct ensembl:ENSMUSG00000038418
Fos GeneProduct ensembl:ENSMUSG00000021250
Mmp12 GeneProduct ensembl:ENSMUSG00000049723
Ifng GeneProduct ensembl:ENSMUSG00000055170
Mbp GeneProduct ensembl:ENSMUSG00000041607
Rtn4 GeneProduct ensembl:ENSMUSG00000020458
Hc GeneProduct ensembl:ENSMUSG00000026874
Cxcl1 GeneProduct ensembl:ENSMUSG00000029380
Cxcl1 GeneProduct ensembl:ENSMUSG00000029380
Aqp4 GeneProduct ensembl:ENSMUSG00000024411
Il1b GeneProduct ensembl:ENSMUSG00000027398
Nos2 GeneProduct ensembl:ENSMUSG00000020826
Tnf GeneProduct ensembl:ENSMUSG00000024401
Arg1 GeneProduct ensembl:ENSMUSG00000019987
Epha4 GeneProduct ensembl:ENSMUSG00000026235
Efnb2 GeneProduct ensembl:ENSMUSG00000001300
Cxcl10 GeneProduct ensembl:ENSMUSG00000034855
Ccng1 GeneProduct ensembl:ENSMUSG00000020326
Mmp9 GeneProduct ensembl:ENSMUSG00000017737
Ncan GeneProduct ensembl:ENSMUSG00000002341
Slit1 GeneProduct ensembl:ENSMUSG00000025020
Slit2 GeneProduct ensembl:ENSMUSG00000031558
Slit3 GeneProduct ensembl:ENSMUSG00000056427
Ntn1 GeneProduct ensembl:ENSMUSG00000020902
Rgma GeneProduct ensembl:ENSMUSG00000070509
Mmp9 GeneProduct ensembl:ENSMUSG00000017737
Mmp9 GeneProduct ensembl:ENSMUSG00000017737
Mmp9 GeneProduct ensembl:ENSMUSG00000017737
Ccr2 GeneProduct ensembl:ENSMUSG00000049103
Il1r1 GeneProduct ensembl:ENSMUSG00000026072
Il1a GeneProduct ensembl:ENSMUSG00000027399
Cxcl1 GeneProduct ensembl:ENSMUSG00000029380
Cxcl2 GeneProduct ensembl:ENSMUSG00000058427
Ccl2 GeneProduct ensembl:ENSMUSG00000035385
Pla2g6 GeneProduct ensembl:ENSMUSG00000042632
Pla2g5 GeneProduct ensembl:ENSMUSG00000041193
Pla2g2a GeneProduct ensembl:ENSMUSG00000058908
Anxa1 GeneProduct ensembl:ENSMUSG00000024659
Icam1 GeneProduct ensembl:ENSMUSG00000037405
Selp GeneProduct ensembl:ENSMUSG00000026580
Klk8 GeneProduct ensembl:ENSMUSG00000064023
Gfap GeneProduct ensembl:ENSMUSG00000020932
Cdk4 GeneProduct ensembl:ENSMUSG00000006728
Tacr1 GeneProduct ensembl:ENSMUSG00000030043
E2f5 GeneProduct ensembl:ENSMUSG00000027552
Rb1 GeneProduct ensembl:ENSMUSG00000022105
Prkca GeneProduct ensembl:ENSMUSG00000050965
E2f1 GeneProduct ensembl:ENSMUSG00000027490
Mapk1 GeneProduct ensembl:ENSMUSG00000063358
Ccnd1 GeneProduct ensembl:ENSMUSG00000070348
Myc GeneProduct ensembl:ENSMUSG00000022346
Gadd45a GeneProduct ensembl:ENSMUSG00000036390
Mapk3 GeneProduct ensembl:ENSMUSG00000063065
Casp3 GeneProduct ensembl:ENSMUSG00000031628
Trp53 GeneProduct ensembl:ENSMUSG00000059552
Chst11 GeneProduct ensembl:ENSMUSG00000034612
Vcan GeneProduct ensembl:ENSMUSG00000021614
Col4a1 GeneProduct ensembl:ENSMUSG00000031502
Xylt1 GeneProduct ensembl:ENSMUSG00000030657
Col2a1 GeneProduct ensembl:ENSMUSG00000022483
Acan GeneProduct ensembl:ENSMUSG00000030607
Bcan GeneProduct ensembl:ENSMUSG00000004892
Sox9 GeneProduct ensembl:ENSMUSG00000000567
Trp53 GeneProduct ensembl:ENSMUSG00000059552
Grin1 GeneProduct ensembl:ENSMUSG00000026959
Vim GeneProduct ensembl:ENSMUSG00000026728
Ppp3ca GeneProduct ensembl:ENSMUSG00000028161
Gap43 GeneProduct ensembl:ENSMUSG00000047261
Fkbp1a GeneProduct ensembl:ENSMUSG00000032966
Il2 GeneProduct ensembl:ENSMUSG00000027720
Mag GeneProduct ensembl:ENSMUSG00000036634
Rtn4 GeneProduct ensembl:ENSMUSG00000020458
Rhoa GeneProduct ensembl:ENSMUSG00000007815
Rhoc GeneProduct ensembl:ENSMUSG00000002233
Rhob GeneProduct ensembl:ENSMUSG00000054364
Rock2 GeneProduct ensembl:ENSMUSG00000020580
Omg GeneProduct ensembl:ENSMUSG00000049612
Rtn4r GeneProduct ensembl:ENSMUSG00000043811
Lilrb3 GeneProduct ensembl:ENSMUSG00000058818
PTGS2 GeneProduct ncbigene:469616
Nox4 GeneProduct ensembl:ENSMUSG00000030562
Mir23b GeneProduct ensembl:ENSMUSG00000065599
Cdk1 GeneProduct ensembl:ENSMUSG00000019942
Gdnf GeneProduct ensembl:ENSMUSG00000022144
Sema6a GeneProduct ensembl:ENSMUSG00000019647
Gja1 GeneProduct ensembl:ENSMUSG00000050953
Bdnf GeneProduct ensembl:ENSMUSG00000048482


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