Regulatory circuits of the STAT3 signaling pathway (WP4538)

Homo sapiens

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STAT3 activation works through phosphorylation on at tyrosine 705 by a variety of adaptor kinases (JAK1, JAK2, JAK3, TYK2, SRC), resulting in dimers of STAT3 that translocates into the nucleus. Those adaptor kinases can be activated by a variety of receptors in response to cytokines or growth factors. Besides, an additional phosphate group can be added at serine 727 on each STAT3 (by MAPKs, mTOR, PKC), which enhances the transcriptional activity of STAT3 or directs STAT3 towards the mitochondria. Inside the nucleus, the STAT3 dimers are regulated by a variety of modifying factors, such as acetylation at lysine 685 by histone acetyltransferases, methylation at lysine 140 by histone methyltransferases to favor or impair STAT3 transcriptional activity, respectively. Other regulators of STAT3 include phosphatases (such as PTPRD, SOCS3, TRIM28, PIAS3) and miRNAs.

Authors

Marvin Martens , Denise Slenter , and Friederike Ehrhart

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway Jak-Stat signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
DUSP2 GeneProduct ncbigene:1844 DUSP2
GHR GeneProduct ncbigene:2690 GHR,
IFNAR1 GeneProduct ncbigene:3454 IFNAR,IFNGR,
IL2RA GeneProduct ncbigene:3559 IL-2R,IL-7R,
IL7R GeneProduct ncbigene:3575 IL-7R,
PTPRC GeneProduct ncbigene:5788 PTPRC
MAPK1 GeneProduct ncbigene:5594 MAPK
CSF2RB GeneProduct hgnc.symbol:CSF2RB
SOCS3 GeneProduct ncbigene:9021 SOCS3
IFNGR1 GeneProduct hgnc.symbol:IFNGR1
MAPKAP1 GeneProduct hgnc.symbol:MAPKAP1
MAPK14 GeneProduct ncbigene:1432 MAPK
CREBBP GeneProduct hgnc.symbol:CREBBP
SRC GeneProduct hgnc.symbol:SRC
MAPK15 GeneProduct hgnc.symbol:MAPK15
PDGFRB GeneProduct hgnc.symbol:PDGFRB
MAPK12 GeneProduct ncbigene:6300 MAPK
OSMR GeneProduct ncbigene:9180 OSMR
SETD7 GeneProduct hgnc.symbol:SETD7
IL10RA GeneProduct hgnc.symbol:IL10RA
MAPK9 GeneProduct ncbigene:5601 MAPK
IL2RB GeneProduct hgnc.symbol:IL2RB
TRIM28 GeneProduct hgnc.symbol:TRIM28
IL20RB GeneProduct hgnc.symbol:IL20RB
IL2RG GeneProduct hgnc.symbol:IL2RG
JAK2 GeneProduct hgnc.symbol:JAK2
CSF2RA GeneProduct hgnc.symbol:CSF2RA
PDGFRA GeneProduct hgnc.symbol:PDGFRA
CSF3R GeneProduct ncbigene:1441 G-CSFR
AGTR1 GeneProduct hgnc.symbol:AGTR1
IL12RB2 GeneProduct hgnc.symbol:IL12RB2
MAPK8 GeneProduct ncbigene:5599 MAPK
IL15RA GeneProduct hgnc.symbol:IL15RA
IL10RB GeneProduct hgnc.symbol:IL10RB
EGFR GeneProduct ncbigene:1956 GM-CSFR(homodimericIL-20R,IL-22R,EGFR,PDGFR
MLST8 GeneProduct hgnc.symbol:MLST8
F2RL3 GeneProduct hgnc.symbol:F2RL3
F2RL2 GeneProduct hgnc.symbol:F2RL2
STAT3 GeneProduct ncbigene:6774 STAT3
MAPK7 GeneProduct hgnc.symbol:MAPK7
IL22RA1 GeneProduct hgnc.symbol:IL22RA1
IFNLR1 GeneProduct hgnc.symbol:IFNLR1
MTOR GeneProduct hgnc.symbol:MTOR
MAPK6 GeneProduct hgnc.symbol:MAPK6
IL3RA GeneProduct hgnc.symbol:IL3RA
LIFR GeneProduct ncbigene:3977 LIFR,OSMR
CTF1 GeneProduct hgnc.symbol:CTF1
AGTR2 GeneProduct hgnc.symbol:AGTR2
MLST8 GeneProduct hgnc.symbol:MLST8
IL20RA GeneProduct hgnc.symbol:IL20RA
IL6R GeneProduct ncbigene:3570 IL-6R,
AKT1S1 GeneProduct hgnc.symbol:AKT1S1
MPL GeneProduct ncbigene:4352 TpoR,
RICTOR GeneProduct hgnc.symbol:RICTOR
PTPRT GeneProduct ncbigene:11122 PTPRT
IL6ST GeneProduct hgnc.symbol:IL6ST
STMN1 GeneProduct hgnc.symbol:STMN1
IL27RA GeneProduct ncbigene:9466 IL-27R,IL-35R,IL-21R(sharedsubunit)
PRKCB GeneProduct hgnc.symbol:PRKCB
IL21R GeneProduct ncbigene:50615 IL-21R
RPTOR GeneProduct hgnc.symbol:RPTOR
MAPK3 GeneProduct ncbigene:5595 MAPK
IFNGR2 GeneProduct hgnc.symbol:IFNGR2
PTPRD GeneProduct hgnc.symbol:PTPRD
F2R GeneProduct hgnc.symbol:F2R
MAPK11 GeneProduct ncbigene:5600 MAPK
MAPK10 GeneProduct ncbigene:5602 MAPK
DEPTOR GeneProduct hgnc.symbol:DEPTOR
PIAS3 GeneProduct ncbigene:10401 PIAS3
MAPK13 GeneProduct ncbigene:5603 MAPK
IL9R GeneProduct ncbigene:3581 IL-9R,
IFNAR2 GeneProduct hgnc.symbol:IFNAR2
IL11RA GeneProduct hgnc.symbol:IL11RA
CNTFR GeneProduct ncbigene:1271 CNTFR,CT-1R,ycsubunit)
IL5RA GeneProduct hgnc.symbol:IL5RA
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
MAPK4 GeneProduct hgnc.symbol:MAPK4
MTOR GeneProduct hgnc.symbol:MTOR
IL6ST GeneProduct hgnc.symbol:IL6ST
IL6ST GeneProduct hgnc.symbol:IL6ST
IL6ST GeneProduct hgnc.symbol:IL6ST
IL6ST GeneProduct hgnc.symbol:IL6ST
IL6ST GeneProduct hgnc.symbol:IL6ST
IL6ST GeneProduct hgnc.symbol:IL6ST
IL6ST GeneProduct hgnc.symbol:IL6ST
IL2RG GeneProduct hgnc.symbol:IL2RG
IL2RG GeneProduct hgnc.symbol:IL2RG
IL2RB GeneProduct hgnc.symbol:IL2RB
IL2RG GeneProduct hgnc.symbol:IL2RG
IL2RG GeneProduct hgnc.symbol:IL2RG
CSF2RB GeneProduct hgnc.symbol:CSF2RB
CSF2RB GeneProduct hgnc.symbol:CSF2RB
GHR GeneProduct ncbigene:2690 GHR,
MPL GeneProduct ncbigene:4352 TpoR,
CSF3R GeneProduct ncbigene:1441 G-CSFR
IL10RB GeneProduct hgnc.symbol:IL10RB
IL10RA GeneProduct hgnc.symbol:IL10RA
IL10RB GeneProduct hgnc.symbol:IL10RB
IL22RA1 GeneProduct hgnc.symbol:IL22RA1
IL20RB GeneProduct hgnc.symbol:IL20RB
IL10RB GeneProduct hgnc.symbol:IL10RB
PDGFRA GeneProduct hgnc.symbol:PDGFRA
PDGFRB GeneProduct hgnc.symbol:PDGFRB
PDGFRB GeneProduct hgnc.symbol:PDGFRB
PDGFRA GeneProduct hgnc.symbol:PDGFRA
JAK1 GeneProduct hgnc.symbol:JAK1
JAK2 GeneProduct hgnc.symbol:JAK2
TYK2 GeneProduct hgnc.symbol:TYK2
JAK1 GeneProduct hgnc.symbol:JAK1
TYK2 GeneProduct hgnc.symbol:TYK2
JAK1 GeneProduct hgnc.symbol:JAK1
JAK3 GeneProduct hgnc.symbol:JAK3
JAK2 GeneProduct hgnc.symbol:JAK2
JAK2 GeneProduct hgnc.symbol:JAK2
TYK2 GeneProduct hgnc.symbol:TYK2
JAK1 GeneProduct hgnc.symbol:JAK1
JAK2 GeneProduct hgnc.symbol:JAK2
JAK2 GeneProduct hgnc.symbol:JAK2
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3
STAT3 GeneProduct ncbigene:6774 STAT3

References

  1. Viral manipulation of STAT3: Evade, exploit, and injure. Roca Suarez AA, Van Renne N, Baumert TF, Lupberger J. PLoS Pathog. 2018 Mar 15;14(3):e1006839. PubMed Europe PMC Scholia