PPAR-alpha pathway (WP2878)

Homo sapiens

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PPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2878 CPTAC Assay Portal]

Authors

Rianne Fijten , Egon Willighagen , Friederike Ehrhart , Alex Pico , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

peroxisome proliferator-activated receptor signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Ligand Metabolite chebi:48705
Ligand Metabolite chebi:48705
PPARA GeneProduct ensembl:ENSG00000186951
RXRA GeneProduct ensembl:ENSG00000186350
PPARA GeneProduct ensembl:ENSG00000186951
RXRA GeneProduct ensembl:ENSG00000186350
ACAA1 GeneProduct ensembl:ENSG00000060971
UGT1A9 GeneProduct ensembl:ENSG00000241119
NR1H3 GeneProduct ensembl:ENSG00000025434
SCP2 GeneProduct ensembl:ENSG00000116171
CPT1A GeneProduct ensembl:ENSG00000110090
APOC3 GeneProduct ensembl:ENSG00000110245
FABP1 GeneProduct ensembl:ENSG00000163586
CCND1 GeneProduct ensembl:ENSG00000110092
PLTP GeneProduct ensembl:ENSG00000100979
DBI GeneProduct ensembl:ENSG00000155368
APOA2 GeneProduct ensembl:ENSG00000158874
CPT2 GeneProduct ensembl:ENSG00000157184
APOA1 GeneProduct ensembl:ENSG00000118137
CYP4A11 GeneProduct ensembl:ENSG00000187048
ACADM GeneProduct ensembl:ENSG00000117054
CDK4 GeneProduct ensembl:ENSG00000135446
CYP7A1 GeneProduct ensembl:ENSG00000167910
MYC GeneProduct ensembl:ENSG00000136997
SLC27A1 GeneProduct ensembl:ENSG00000130304
KLK15 GeneProduct ensembl:ENSG00000174562
APOA5 GeneProduct ensembl:ENSG00000110243
CDK1 GeneProduct ensembl:ENSG00000170312
CYP8B1 GeneProduct ensembl:ENSG00000180432
EHHADH GeneProduct ensembl:ENSG00000113790

References

  1. Peroxisome proliferator-activated receptor alpha target genes. Mandard S, Müller M, Kersten S. Cell Mol Life Sci. 2004 Feb;61(4):393–416. PubMed Europe PMC Scholia
  2. PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. Li AC, Glass CK. J Lipid Res. 2004 Dec;45(12):2161–73. PubMed Europe PMC Scholia
  3. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Handschin C, Meyer UA. Arch Biochem Biophys. 2005 Jan 15;433(2):387–96. PubMed Europe PMC Scholia
  4. Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, et al. Nucl Recept. 2005 Oct 3;3:3. PubMed Europe PMC Scholia
  5. From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Bock KW. Biochem Pharmacol. 2011 Jul 1;82(1):9–16. PubMed Europe PMC Scholia
  6. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia