Osteopontin signaling (WP1434)

Homo sapiens

Open in new tab Open in NDEx
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Study of regulation of promatrix metalloproteinase-9 (MMP-9) by osteopontin (OPN) through IKK signaling pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1434 CPTAC Assay Portal]

Authors

Luigi Maiorana , Thomas Kelder , Kristina Hanspers , Alex Pico , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited By

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway signaling pathway pertinent to development

Participants
Query Drugst.One

Label Type Compact Identifier Comment
RELA GeneProduct ncbigene:5970
RELA GeneProduct ncbigene:5970
IKK-alpha GeneProduct ncbigene:1147
PLAU GeneProduct ncbigene:5328
ERK2 GeneProduct ncbigene:5594
IKK-beta GeneProduct ncbigene:3551
MEK1 GeneProduct ncbigene:5604
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
NIK GeneProduct ncbigene:9020
ITGAV GeneProduct ncbigene:3685
ITGB3 GeneProduct ncbigene:3690
NFKB1 GeneProduct ncbigene:4790
MMP-9 GeneProduct ncbigene:4318
NIK GeneProduct ncbigene:9020
NFKB1 GeneProduct ncbigene:4790
SPP1 GeneProduct ncbigene:6696
ERK1 GeneProduct ncbigene:5595
NFKB1 GeneProduct ncbigene:4790

References

  1. Osteopontin: it’s role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression. Das R, Philip S, Mahabeleshwar GH, Bulbule A, Kundu GC. IUBMB Life. 2005 Jun;57(6):441–7. PubMed Europe PMC Scholia