Osteopontin signaling (WP1434)

Homo sapiens

Study of regulation of promatrix metalloproteinase-9 (MMP-9) by osteopontin (OPN) through IKK signaling pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1434 CPTAC Assay Portal]


Luigi Maiorana , Thomas Kelder , Kristina Hanspers , Alex Pico , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

signaling pathway signaling pathway pertinent to development


Label Type Compact URI Comment
RELA GeneProduct ncbigene:5970
RELA GeneProduct ncbigene:5970
IKK-alpha GeneProduct ncbigene:1147
PLAU GeneProduct ncbigene:5328
ERK2 GeneProduct ncbigene:5594
IKK-beta GeneProduct ncbigene:3551
MEK1 GeneProduct ncbigene:5604
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
NIK GeneProduct ncbigene:9020
ITGAV GeneProduct ncbigene:3685
ITGB3 GeneProduct ncbigene:3690
NFKB1 GeneProduct ncbigene:4790
MMP-9 GeneProduct ncbigene:4318
NIK GeneProduct ncbigene:9020
NFKB1 GeneProduct ncbigene:4790
SPP1 GeneProduct ncbigene:6696
ERK1 GeneProduct ncbigene:5595
NFKB1 GeneProduct ncbigene:4790


  1. Osteopontin: it’s role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression. Das R, Philip S, Mahabeleshwar GH, Bulbule A, Kundu GC. IUBMB Life. 2005 Jun;57(6):441–7. PubMed Europe PMC Scholia