MAPK cascade (WP422)

Homo sapiens

The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Nathan Salomonis , Kristina Hanspers , Ismael Reyes , Michiel Adriaens , Jildau Bouwman , Martijn Van Iersel , Daniela Digles , Martina Summer-Kutmon , Denise Slenter , Alex Pico , Eric Weitz , and Egon Willighagen


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Homo sapiens



Pathway Ontology

mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway


Label Type Compact URI Comment
GTP Metabolite cas:2564-35-4
GDP Metabolite cas:146-91-8
MAPK14 GeneProduct ncbigene:1432
JUN GeneProduct ncbigene:3725
NRAS GeneProduct ncbigene:4893
MAP2K7 GeneProduct ncbigene:5609
MAP3K3 GeneProduct ncbigene:4215
MAP3K1 GeneProduct ncbigene:4214
ELK1 GeneProduct ncbigene:2002
MAP2 GeneProduct ncbigene:4133
MAP2K4 GeneProduct ncbigene:6416
HRAS GeneProduct ncbigene:3265
MAP3K12 GeneProduct ncbigene:7786
MAPK10 GeneProduct ncbigene:5602
MBP GeneProduct ncbigene:4155
MAPK12 GeneProduct ncbigene:6300
MAP2K6 GeneProduct ncbigene:5608
SIPA1 GeneProduct ncbigene:6494 not confirmed SwissProt ID - mu: SPA1 MOUSE
RASA3 GeneProduct ncbigene:22821
RRAS GeneProduct ncbigene:6237
KRAS GeneProduct ncbigene:3845
MAP3K2 GeneProduct ncbigene:10746
MAP2K3 GeneProduct ncbigene:5606
PLCB3 GeneProduct ncbigene:5331
GRB2 GeneProduct ncbigene:2885
SOS2 GeneProduct ncbigene:6655
SOS1 GeneProduct ensembl:ENSG00000115904
ARAF GeneProduct ensembl:ENSG00000078061
BRAF GeneProduct ncbigene:673
RAF1 GeneProduct ncbigene:5894
MAP2K1 GeneProduct ncbigene:5604
MAPK1 GeneProduct ncbigene:5594
MAPK3 GeneProduct ncbigene:5595
MP1 GeneProduct ncbigene:8649
MAP2K2 GeneProduct ncbigene:5605


  1. Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR. IET Syst Biol. 2008 Jul;2(4):173–83. PubMed Europe PMC Scholia
  2. The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Plotnikov A, Zehorai E, Procaccia S, Seger R. Biochim Biophys Acta. 2011 Sep;1813(9):1619–33. PubMed Europe PMC Scholia