COVID-19 structural coverage map (WP5145)

Homo sapiens

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This pathway summarizes the structural relationships (mimicking or hijacking) between COVID-19 (SARS-CoV-2) viral proteins and human proteins.

Authors

Martina Summer-Kutmon , Nhung Pham , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

COVID-19

Pathway Ontology

infectious disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PF-07321332 (Pfizer PAXLOVID) Metabolite drugbank:DB16691
ISG15 Protein uniprot:P05161
nsp13 Protein ncbiprotein:YP_009725308
APOA1 Protein uniprot:P02647
E Protein uniprot:P0DTC4
PARP14 Protein uniprot:Q460N5
UBA52 Protein uniprot:P62987
Spike Protein uniprot:P0DTC2
UBB Protein uniprot:P0CG47
PAIP1 Protein uniprot:Q9H074
PARP9 Protein uniprot:Q8IXQ6
nsp3 Protein ncbiprotein:YP_009725299
CMTR1 Protein uniprot:Q8N1G2
NRP1 Protein uniprot:O14786
ACE2 Protein uniprot:Q9BYF1
orf9b Protein uniprot:P0DTD2
SLC6A19 Protein uniprot:Q695T7
MPP5 Protein uniprot:Q8N3R9
MRM2 Protein uniprot:Q9UI43
MACROD1 Protein uniprot:Q9BQ69
orf3a Protein uniprot:P0DTC6
nsp1 Protein ncbiprotein:YP_009725297
IGHMBP2 Protein uniprot:P38935
UBC Protein uniprot:P0CG48
GDAP2 Protein uniprot:Q9NXN4
MACROD2 Protein uniprot:A1Z1Q3
TOMM70 Protein uniprot:O94826
nsp16 Protein ncbiprotein:YP_009725311
MACROH2A1 Protein uniprot:O75367
UPF1 Protein uniprot:Q92900
AQR Protein uniprot:O60306
MACROH2A1 Protein uniprot:Q9P0M6
UPF2 Protein uniprot:Q9HAU5
nsp5 Protein ncbiprotein:YP_009725301
TAB1 Protein uniprot:Q15750
NLRP12 Protein uniprot:P59046

References

  1. SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species. Moustaqil M, Ollivier E, Chiu HP, Van Tol S, Rudolffi-Soto P, Stevens C, et al. Emerg Microbes Infect. 2021 Dec;10(1):178–95. PubMed Europe PMC Scholia
  2. Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations. Ahmad B, Batool M, Ain QU, Kim MS, Choi S. Int J Mol Sci. 2021 Aug 24;22(17):9124. PubMed Europe PMC Scholia
  3. SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms. O’Donoghue SI, Schafferhans A, Sikta N, Stolte C, Kaur S, Ho BK, et al. Mol Syst Biol. 2021 Sep;17(9):e10079. PubMed Europe PMC Scholia