Caffeine and theobromine metabolism (WP3633)

Homo sapiens

Metabolism pathway of two compounds commonly found in human samples: caffeine and theobromine.


Egon Willighagen , Denise Slenter , Eric Weitz , and Marvin Martens


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Homo sapiens



Pathway Ontology

caffeine metabolic pathway xenobiotic metabolic pathway


Label Type Compact URI Comment
theobromine Metabolite hmdb:HMDB0002825
Xanthine Metabolite hmdb:HMDB0000292
AFMU Metabolite chebi:32643
1-methyluric acid Metabolite hmdb:HMDB0003099
3,7-dimethyluric acid Metabolite hmdb:HMDB0001982
caffeine Metabolite hmdb:HMDB0001847
paraxanthine Metabolite hmdb:HMDB0001860
1-methylxanthine Metabolite hmdb:HMDB0010738
1,7-dimethyluric acid Metabolite hmdb:HMDB0011103
7-methylxanthine Metabolite hmdb:HMDB0001991
7-methyluric acid Metabolite hmdb:HMDB0011107
CYP1A2 GeneProduct ensembl:ENSG00000140505
XDH GeneProduct ensembl:ENSG00000158125
CYP1A2 GeneProduct ensembl:ENSG00000140505
NAT2 GeneProduct ensembl:ENSG00000156006
XDH GeneProduct ensembl:ENSG00000158125 Generally: EC
CYP1A2 GeneProduct ensembl:ENSG00000140505
CYP2A6 GeneProduct ensembl:ENSG00000255974
XDH GeneProduct ensembl:ENSG00000158125


  1. Variability in caffeine metabolism. Grant DM, Tang BK, Kalow W. Clin Pharmacol Ther. 1983 May;33(5):591–602. PubMed Europe PMC Scholia