Matrix metalloproteinases (WP129)

Homo sapiens

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Kdahlquist , Martijn Van Iersel , Kristina Hanspers , Thomas Kelder , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


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Homo sapiens



Pathway Ontology

cell-extracellular matrix signaling pathway protein degradation pathway


Label Type Compact URI Comment
MMP2 GeneProduct ncbigene:4313
MMP9 GeneProduct ncbigene:4318
MMP7 GeneProduct ncbigene:4316
MMP12 GeneProduct ncbigene:4321
MMP20 GeneProduct ncbigene:9313
MMP10 GeneProduct ncbigene:4319
MMP3 GeneProduct ncbigene:4314
MMP11 GeneProduct ncbigene:4320
MMP19 GeneProduct ncbigene:4327
MMP14 GeneProduct ncbigene:4323
MMP15 GeneProduct ncbigene:4324
MMP16 GeneProduct ncbigene:4325
MMP17 GeneProduct ncbigene:4326
MMP24 GeneProduct ncbigene:10893
TIMP2 GeneProduct ncbigene:7077
TIMP3 GeneProduct ncbigene:7078
TIMP4 GeneProduct ncbigene:7079
BSG GeneProduct ncbigene:682
TNF GeneProduct ncbigene:7124
MMP26 GeneProduct ncbigene:56547
MMP28 GeneProduct ncbigene:79148
MMP23A GeneProduct ensembl:ENSG00000215914
MMP25 GeneProduct ncbigene:64386
MMP27 GeneProduct ncbigene:64066
TCF20 GeneProduct ncbigene:6942
MMP21 GeneProduct ncbigene:118856
MMP1 GeneProduct ncbigene:4312
MMP8 GeneProduct ncbigene:4317
MMP13 GeneProduct ncbigene:4322
TIMP1 GeneProduct ncbigene:7076
MMP23B GeneProduct ncbigene:8510


  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia