p38 MAPK signaling pathway (WP803)

Gallus gallus

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Authors

Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

p38 MAPK signaling pathway

Participants

Label Type Compact URI Comment
MAPKAPK2 GeneProduct ensembl:ENSGALG00000000883 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9261
GRB2 GeneProduct ensembl:ENSGALG00000008016 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2885
TRAF2 GeneProduct ensembl:ENSGALG00000042838 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7186
MAPKAPK5 GeneProduct ensembl:ENSGALG00000004743 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8550
HSPB1 GeneProduct ensembl:ENSGALG00000001926 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3315
SHC1 GeneProduct ensembl:ENSGALG00000039775 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6464
MAP2K6 GeneProduct ensembl:ENSGALG00000004370 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5608
MAP3K9 GeneProduct ensembl:ENSGALG00000037326 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4293
cRac1A GeneProduct ensembl:ENSGALG00000007130 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5879
ChALK5 GeneProduct ensembl:ENSGALG00000033179 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7046
MEF2D GeneProduct ensembl:ENSGALG00000037787 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4209
ATF2 GeneProduct ensembl:ENSGALG00000009287 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1386
STAT1 GeneProduct ensembl:ENSGALG00000007651 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6772
CREB1 GeneProduct ensembl:ENSGALG00000041244 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1385
MAP3K5 GeneProduct ensembl:ENSGALG00000013892 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4217
MKNK1 GeneProduct ensembl:ENSGALG00000010440 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8569
MAP3K7 GeneProduct ensembl:ENSGALG00000015596 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6885
RIPK1 GeneProduct ensembl:ENSGALG00000012827 receptor (TNFRSF)-interacting serine-threonine kinase 1
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8737
RPS6KA5 GeneProduct ensembl:ENSGALG00000030580 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9252
MAPK14 GeneProduct ensembl:ENSGALG00000042833 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1432
MAX GeneProduct ensembl:ENSGALG00000032249 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4149
HRAS GeneProduct ensembl:ENSGALG00000040551 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3265
CDC42 GeneProduct ensembl:ENSGALG00000004796 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:998
HMGN1 GeneProduct ensembl:ENSGALG00000033985 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3150
PLA2G4A GeneProduct ensembl:ENSGALG00000005065 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5321
MAP2K4 GeneProduct ensembl:ENSGALG00000032178 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6416
RASGRF1 GeneProduct ensembl:ENSGALG00000008262 PDZ domain containing guanine nucleotide exchange
Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5923
TGFB2 GeneProduct ensembl:ENSGALG00000009612 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7042
MAP3K1 GeneProduct ensembl:ENSGALG00000014718 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4214
MYC GeneProduct ensembl:ENSGALG00000033631 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
TRADD GeneProduct ensembl:ENSGALG00000003195 Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8717

References

  1. Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone. Roberson MS, Zhang T, Li HL, Mulvaney JM. Endocrinology. 1999 Mar;140(3):1310–8. PubMed Europe PMC Scholia
  2. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3763–8. PubMed Europe PMC Scholia
  3. Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses. Kyriakis JM. Biochem Soc Symp. 1999;64:29–48. PubMed Europe PMC Scholia
  4. The stress-activated protein kinase pathways. Tibbles LA, Woodgett JR. Cell Mol Life Sci. 1999 Aug 15;55(10):1230–54. PubMed Europe PMC Scholia
  5. p38 MAPK signalling cascades in inflammatory disease. Herlaar E, Brown Z. Mol Med Today. 1999 Oct;5(10):439–47. PubMed Europe PMC Scholia
  6. Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin. Li S, Wattenberg EV. Toxicol Appl Pharmacol. 1999 Oct 15;160(2):109–19. PubMed Europe PMC Scholia
  7. From receptors to stress-activated MAP kinases. Ichijo H. Oncogene. 1999 Nov 1;18(45):6087–93. PubMed Europe PMC Scholia
  8. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, et al. Mol Cell. 2000 Dec;6(6):1343–54. PubMed Europe PMC Scholia