Secretion of hydrochloric acid in parietal cells (WP2597)

Homo sapiens

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Gastric parietal cells are stomach epithelial cells. They secrete gastric acid and intrinsic factor. This pathway is primarily based on https://en.wikipedia.org/wiki/Parietal_cell

Authors

Andra Waagmeester , Martina Summer-Kutmon , Linda Rieswijk , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

epithelial cell of stomach epithelial cell parietal cell

Pathway Ontology

acid-base homeostasis pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Chloride ion Metabolite hmdb:HMDB0000492
Acetylcholine Metabolite chemspider:182
Potassium Metabolite hmdb:HMDB0000586
Histamine Metabolite chemspider:753
Carbon dioxide Metabolite chemspider:274
Water Metabolite chemspider:937
Bicarbonate ion Metabolite chemspider:749
Zinc Metabolite chemspider:22430
Hydrogen Metabolite hmdb:HMDB0059597
Bicarbonate ion Metabolite chemspider:749
Hydrogen Metabolite hmdb:HMDB0059597
Chloride ion Metabolite hmdb:HMDB0000492
Potassium Metabolite hmdb:HMDB0000586
Chloride ion Metabolite hmdb:HMDB0000492
Gastrin GeneProduct uniprot:P01350
ATP4A GeneProduct ncbigene:495
HRH2 GeneProduct ncbigene:3274
CHRM1 GeneProduct ncbigene:1128
CCKBR GeneProduct ncbigene:887

References

  1. Purification and characterization of human salivary carbonic anhydrase. Murakami H, Sly WS. J Biol Chem. 1987 Jan 25;262(3):1382–8. PubMed Europe PMC Scholia